Alleviation of diabetic microangiopathy in rats by pancreatic islet cell transplantation
Alleviation of diabetic microangiopathy in rats by pancreatic islet cell transplantation
复制标题
胰岛细胞移植减轻大鼠糖尿病微血管病变
作者：
I. Lauder;J. Abascal;R. Cartwright;J. Farndon;I. Johnston
通过注射链脲佐菌素在雌性 WAG 大鼠中诱发糖尿病。在肾脏和其他器官中研究了由此产生的糖尿病微血管病变，并评估了胰岛细胞移植在预防和逆转微血管并发症方面的有效性。研究发现，1000多个胰岛的门静脉移植可使大多数动物的代谢正常，并且成功的移植可预防糖尿病微血管病的发展。很早期的病变可以完全恢复正常。这些发现有力地支持了人类糖尿病患者良好的代谢控制以防止微血管病变损伤的必要性。
Diabetes was induced in female WAG rats by an injection of streptozotocin. The resultant diabetic microangiopathy was studied in the kidney and other organs and the effectiveness of pancreatic islet cell transplantation in preventing and reversing the microvascular complications was assessed. It was found that intraportal transplants of more than 1000 islets produced metabolic normality in most animals and successful transplants prevented the development of diabetic microangiopathy. Very early lesions could be completely restored to normal. The findings strongly support the necessity of good metabolic control of human diabetic patients to prevent microangiopathic damage.