Amyotrophic Lateral Sclerosis and Exposure to Diesel Exhaust in a Danish Cohort
Amyotrophic Lateral Sclerosis and Exposure to Diesel Exhaust in a Danish Cohort
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DOI：
10.1093/aje/kwy069
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发表时间：
2018-08-01
影响因子：
5
通讯作者：
Weisskopf, Marc G.
中科院分区：
文献类型：
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作者：
Dickerson, Aisha S.;Hansen, Johnni;Weisskopf, Marc G.
以前的研究表明，从事通常涉及柴油尾气(DE)暴露的职业的人患肌萎缩侧索硬化症(ALS)和其他运动神经元疾病的风险增加。在这项研究中，我们调查了职业性暴露于DE与ALS发病几率之间的关系。ALS病例是从丹麦国家患者登记处确认的(1982-2013年)，并根据出生年份和性别分别与每个病例的100名对照进行匹配。使用从丹麦养老基金获得的1964年以来的职业史信息，我们使用工作暴露矩阵估计了累积的DE暴露。我们使用条件Logistic回归分析对关联进行评估，并按性别对分析进行分层。使用10年的滞后期，在曾经接触过DE的男性中，DE暴露与ALS呈正相关(调整后的优势比(AOR)=1.20，95%可信区间(CI)：1.05，1.38)。对于DE暴露概率大于50%的男性，我们观察到ALS与5年(AOR=1.35，95%CI：1.07，1.70)和10年(AOR=1.41，95%CI：1.11，1.79)滞后期暴露的最高四分位数呈正相关。我们的研究表明，在男性中，持续较高的DE暴露与ALS之间存在关联，但在女性中则不是。这些发现支持了先前关于肌萎缩侧索硬化症与职业之间的关联的报道，这些职业通常涉及DE暴露。
Previous studies have suggested an increased risk of amyotrophic lateral sclerosis (ALS) and other motor neuron diseases for persons in occupations commonly involving exposure to diesel exhaust (DE). In this study, we investigated the association between occupational exposure to DE and odds of ALS. ALS cases were identified from the Danish National Patient Registry (1982-2013) and individually matched to 100 controls per case on the basis of birth year and sex. Using information on occupational history from 1964 onward obtained from the Danish Pension Fund, we estimated cumulative DE exposures using a job exposure matrix. We evaluated associations using conditional logistic regression analyses and stratified the analyses by sex. Using a 10-year lag period, DE exposure was positively associated with ALS among men who had ever been exposed (adjusted odds ratio (aOR) = 1.20, 95% confidence interval (CI): 1.05, 1.38). For men with greater than 50% probability of DE exposure, we observed a positive association between ALS and highest-quartile exposure during the 5-year (aOR = 1.35, 95% CI: 1.07, 1.70) and 10-year (aOR = 1.41, 95% CI: 1.11, 1.79) lag periods. Our study suggests an association between consistently higher exposures to DE and ALS in men, but not in women. These findings support previous reports of associations between ALS and occupations commonly involving DE exposure.