Multiple biomarkers based appraisal of deltamethrin induced toxicity in silver carp (Hypophthalmichthys molitrix)
Multiple biomarkers based appraisal of deltamethrin induced toxicity in silver carp (Hypophthalmichthys molitrix)
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DOI：
10.1016/j.chemosphere.2018.09.145
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发表时间：
2019-01-01
期刊：
影响因子：
8.8
通讯作者：
Fahad, Shah
中科院分区：
文献类型：
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作者：
Ullah, Sana;Li, Zhongqiu;Fahad, Shah
溴氰菊酯（DLM）是α-氰基（II型）合成拟除虫菊酯。DLM暴露导致强烈的神经毒性作用和许多复杂的毒理学综合征。本研究评价了DLM介导的氧化应激对银（Hypophthalmichthys molitrix）的行为、血液学、组织病理学和生化毒性效应。急性浓度（2 μ/L）的DLM暴露导致银鲤不同程度的行为不一致，血液学和血清生化指标发生显著（P < 0.05）的时间依赖性变化。肝脏、鳃、脑和肌肉组织中活性氧、脂质过氧化和抗氧化酶活性显著升高（P < 0.05），总蛋白含量显著降低。DLM暴露增加了银鲤鳃、肌肉和肝脏中代谢酶的活性。外周血红细胞DNA损伤明显增加（P < 0.05）。DLM暴露后，大鼠全身皮质醇和血糖水平呈时间依赖性显著升高（P < 0.05），而脑、肝和肌肉组织中乙酰胆碱酯酶活性显著降低（P < 0.05）。在肝脏，鳃，脑，肠观察到不同的组织病理学变化，但是，没有观察到鱼的大体解剖和形态测量参数的显着变化。本研究为制定更好的环境管理、化学品风险评估、生物多样性保护和水生生物监测策略提供了有价值的信息。DLM被认为对鱼类有剧毒。DLM的广泛使用应在严格的环境法律下被禁止或允许;否则，它可能导致易感野生动物的灭绝，例如商业上非常有价值但几乎受到威胁的银鱼。(C)2018爱思唯尔有限公司版权所有。
Deltamethrin (DLM) is alpha-cyano (type II) synthetic pyrethroid. DLM exposure leads to strong neurotoxic effects and a number of complex toxicological syndromes. The current study assessed DLM mediated oxidative stress, behavioral, hematological, histopathological, and biochemical toxic effects on silver carp (Hypophthalmichthys molitrix). Exposure to an acute concentration (2 mu/L) of DLM resulted in different behavioral inconsistencies and a time-dependent significant (P < 0.05) change in the hematology and serum biochemistry of silver carp. A significant (P < 0.05) increase in the activities of reactive oxygen species, lipid peroxidation, and antioxidant enzymes whereas a significant decrease in total protein contents in the liver, gills, brain, and muscle tissues were observed. DLM exposure increased the activities of metabolic enzymes in the gills, muscles, and liver of silver carp. A significant (P < 0.05) increase in DNA damage in peripheral blood erythrocytes was evident. DLM exposure led to a time-dependent significant (P < 0.05) increase in the whole-body cortisol and blood glucose level, while a significant decrease in acetylcholine esterase activity in the brain, liver, and muscle tissues. Different histopathological changes in the liver, gills, brain, and intestine were observed, however, no significant change in the gross anatomy and morphometric parameters of the fish was observed. The current study provides valuable information for devising better strategies regarding environmental management, chemicals' risk assessment, biodiversity conservation, and monitoring of the aquatic organisms. DLM was concluded to be highly toxic to fish. The extensive use of DLM should be prohibited or allowed under strict environmental laws; otherwise, it might lead to the extermination of the susceptible wildlife, such as commercially very valuable but nearly threatened silver carp. (C) 2018 Elsevier Ltd. All rights reserved.