Breastmilk intake among exclusively breastfed Indonesian infants is negatively associated with maternal fat mass
Breastmilk intake among exclusively breastfed Indonesian infants is negatively associated with maternal fat mass
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DOI：
10.1038/s41430-019-0458-1
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发表时间：
2019-08-01
影响因子：
4.7
通讯作者：
Gibson, Rosalind S.
中科院分区：
文献类型：
--
作者：
Diana, Aly;Haszard, Jillian J.;Gibson, Rosalind S.
母体脂肪量过多可能会损害乳汁生成，导致母乳量减少。我们调查了这种关系，在印尼农村纯母乳喂养的母亲-婴儿（2-5.3个月）二对（n = 112）通过测量母乳摄入量的氧化氘剂量给母亲的技术（DDMT）和母亲的脂肪量的DDMT，生物电阻抗分析（BIA），体重指数（BMI）。我们还比较了DDMT和BIA评估的脂肪量。在该人群中，我们发现母乳摄入量与DDMT测量的母体脂肪量之间存在显著负相关（β = -5.04 mL，95% CI：-9.36，-0.72，P = 0.023），在调整社会经济地位、母亲年龄、婴儿年龄和性别后，与BIA和BMI存在类似但略弱的负相关趋势。通过BIA和DDMT估计的母体脂肪量显示出良好的一致性。鉴于全球超重和肥胖的趋势，需要进一步研究这种负面关系的潜在机制。
Excessive maternal fat mass may impair lactogenesis and lead to lower breastmilk volume. We investigated this relationship in rural Indonesian exclusively breastfeeding mother-infant (2-5.3 months) dyads (n = 112) by measuring breastmilk intake by deuterium oxide dose-to-mother technique (DDMT) and maternal fat mass by DDMT, bioelectrical impedance analysis (BIA), and body mass index (BMI). We also compared fat mass assessed by DDMT and BIA. In this population, we found a significant negative relationship between breastmilk intake and maternal fat mass measured by DDMT (beta = -5.04 mL, 95% CI: -9.36, -0.72, P = 0.023), and similar but slightly weaker negative trend with BIA and BMI, after adjusting for social-economic status, maternal age, infant age and sex. Maternal fat mass estimates by BIA and DDMT showed good agreement. In light of the trend for overweight and obesity worldwide, further research is needed into the underlying mechanisms of this negative relationship.