Effect of Cu- and Zn-Doped Bioactive Glasses on the In Vitro Bioactivity, Mechanical and Degradation Behavior of Biodegradable PDLLA Scaffolds
Effect of Cu- and Zn-Doped Bioactive Glasses on the In Vitro Bioactivity, Mechanical and Degradation Behavior of Biodegradable PDLLA Scaffolds
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DOI：
10.3390/ma13132908
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发表时间：
2020-07-01
期刊：
影响因子：
3.4
通讯作者：
Palza, Humberto
中科院分区：
文献类型：
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作者：
Bejarano, Julian;Boccaccini, Aldo R.;Palza, Humberto
掺入治疗性金属离子的生物活性玻璃颗粒填充的可生物降解聚合物支架是修复临界大小骨缺损的一种新颖而有前途的策略。本研究采用冷冻干燥和盐析法制备了未掺杂和铜、锌、铜掺杂生物活性玻璃颗粒填充的聚(D，L-丙交酯)基质支架。考察了玻璃颗粒的掺杂量和含量(10%和30%)对支架的形貌、压缩性能、磷灰石形成和降解行为的影响。支架具有较高的孔隙率(接近93%)，孔隙率在100~400微米之间，由较小的孔洞连接，并在玻璃颗粒的作用下保持这种孔隙率。玻璃颗粒增强了聚合物支架，弹性模量提高了130%，并进一步促进了支架表面磷灰石的形成，这两种性能都取决于填料的数量和类型。生物活性玻璃颗粒促进了支架的降解，其中PDLLA/非掺杂玻璃支架的降解率最高，但仍保持了结构和尺寸的完整性。我们的研究结果表明，未掺杂和金属掺杂的生物活性玻璃的加入增加了聚合物/玻璃支架的机械强度，促进了生物活性，并改变了其降解曲线，使其更适合骨修复。
Biodegradable polymer scaffolds filled with bioactive glass particles doped with therapeutic metal ions are a novel and promising strategy to repair critical-sized bone defects. In this study, scaffolds based on a poly (D, L-lactide acid) (PDLLA) matrix filled with un-doped and Cu-, Zn- and CuZn-doped bioactive glass particles were produced by freeze-drying and a salt-leaching method. The effects of the doping and content of the glass particles (10 and 30 wt.%) on the morphology, compression properties, apatite formation, and degradation behavior of the scaffolds were evaluated. The scaffolds presented high porosity (similar to 93%) with pores ranged from 100 to 400 mu m interconnected by smaller pores and this porosity was kept after the glass particles incorporation. The glass particles reinforced the polymer scaffolds with improvements as high as 130% in elastic moduli, and further promoted the apatite formation on the scaffold surface, both properties depending on the amount and type of filler. The bioactive glass particles boosted the scaffold degradation with the PDLLA/un-doped glass scaffold showing the highest rate, but still retaining structural and dimensional integrity. Our findings show that the incorporation of un-doped and metal-doped bioactive glasses increases the mechanical strength, promotes the bioactivity and modifies the degradation profile of the resulting polymer/glass scaffolds, making them better candidates for bone repair.