Tuning radical reactivity using iodine in oxidative C(sp(3))-H/C(sp)-H cross-coupling: an easy way toward the synthesis of furans and indolizines.
Tuning radical reactivity using iodine in oxidative C(sp(3))-H/C(sp)-H cross-coupling: an easy way toward the synthesis of furans and indolizines.
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DOI：
10.1039/c5cc01825k
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发表时间：
2015-05
影响因子：
4.9
通讯作者：
Shan Tang;Kun Liu;Yue Long;X. Qi;Y. Lan;A. Lei
中科院分区：
文献类型：
--
作者：
Shan Tang;Kun Liu;Yue Long;X. Qi;Y. Lan;A. Lei
分子碘被发现是一种有效的氧化还原催化剂，用于羰基化合物与末端炔的氧化交叉偶联反应。在这项工作中，我们证明了碘可以通过可逆的C-I键的形成来调节自由基的反应性，从而控制反应的选择性。这种碘催化方案为合成各种呋喃和中氮杂环化合物提供了一种简便的方法。
Molecular iodine was found to be an effective redox catalyst for the oxidative cross-coupling of carbonyl compounds with terminal alkynes. In this work, we demonstrated that iodine could tune radical reactivity through reversible C-I bond formation for controlling the reaction selectivity. This iodine catalysis protocol provided an easy way for the synthesis of various furans and indolizines.