Associations between schizotypal features and indicators of neurological and morphological abnormalities
Associations between schizotypal features and indicators of neurological and morphological abnormalities
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DOI：
10.1016/j.schres.2007.01.018
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发表时间：
2007-05-01
影响因子：
4.5
通讯作者：
Walker, Elaine F.
中科院分区：
文献类型：
--
作者：
Bollini, Annie M.;Compton, Michael T.;Walker, Elaine F.
目的：有限的研究表明，精神分裂症患者中记录的细微神经和形态异常也可能与非精神病样本中的精神分裂特征相关。基于神经软体征（NSS）可能标志着遗传素质的观点，本研究假设 NSS 评分可能与精神分裂症患者亲属和对照组的精神分裂水平相关。此外，还探讨了这两组中 MPA 评分与精神分裂症之间的关联。 方法：使用 DSM-IV 轴 11 障碍精神分裂型人格障碍模块的结构化临床访谈以及自填精神分裂症人格问卷，对 26 名精神分裂症患者的一级亲属和 38 名无精神病个人或家族史的对照者进行精神分裂症评估。还进行了神经学评估量表和 MPA 结构化检查。结果：亲属和对照之间的平均精神分裂评分没有差异。 NSS 和 MPA 均与访谈者评估的对照组精神分裂特征水平相关，但与精神分裂症患者亲属无关。 NSS 和 MPA 与两组中自我报告的精神分裂症均无关。结论：这些发现表明，NSS 和 MPA 都与基于访谈的精神分裂特征相关，至少在非精神病参与者中是如此。未来的研究应该寻求在亲属和对照的其他样本中复制这些结果。 (c) 2007 Elsevier B.V. 保留所有权利。
Objective: Limited research suggests that subtle neurological and morphological abnormalities that have been documented in patients with schizophrenia also may be associated with schizotypal traits in non-psychiatric samples. Based on the notion that neurological soft signs (NSS) may mark a genetic diathesis, this study hypothesized that NSS scores would be related to the level of schizotypy in relatives of schizophrenia patients and in controls. Additionally, associations between MPA scores and schizotypy were explored in these two groups.Method: Twenty-six first-degree relatives of schizophrenia patients and 38 controls with no personal or family history of psychosis were assessed for schizotypy using the Structured Clinical Interview for DSM-IV Axis 11 Disorders schizotypal personality disorder module, as well as the self-administered Schizotypal Personality Questionnaire. The Neurological Evaluation Scale and a structured examination for MPAs also were administered.Results: Mean schizotypy scores did not differ between relatives and controls. Both NSS and MPAs were associated with the level of interviewer-assessed schizotypal features in controls but not in relatives of patients with schizophrenia. NSS and MPAs were not associated with self-reported schizotypy in either group.Conclusions: These findings demonstrate that both NSS and MPAs are associated with interview-based schizotypal traits, at least in non-psychiatric participants. Future research should seek to replicate these results in other samples of relatives and controls. (c) 2007 Elsevier B.V. All rights reserved.