Brain Serotonin and Dopamine Transporter Bindings in Adults With High-Functioning Autism
Brain Serotonin and Dopamine Transporter Bindings in Adults With High-Functioning Autism
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DOI：
10.1001/archgenpsychiatry.2009.137
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发表时间：
2010-01-01
影响因子：
--
通讯作者：
Mori, Norio
中科院分区：
文献类型：
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作者：
Nakamura, Kazuhiko;Sekine, Yoshimoto;Mori, Norio
内容：自闭症是一种神经发育障碍，其特征在于重复和/或强迫性兴趣和行为以及社交和沟通方面的缺陷。虽然它的神经生物学基础被假定为在于异常的多巴胺能和多巴胺能系统，细节仍然unknowed.Objective：为了确定发生的变化，在结合的5-羟色胺和多巴胺转运体，这是高度选择性的标志物，为各自的神经系统。设计：使用正电子发射断层扫描，我们用放射性配体碳11（C-11）标记的反式-1，2，3，5，6，分别为10-β-六氢-6-[4（甲硫基）苯基]吡咯并-[2，1-a]异喹啉（[C-11]（+）McN-5652）和2 β-甲氧羰基-3-β-（4-氟苯基）托烷（[C-11]WIN-35，428）。统计参数映射用于受试者间分析和受试者内相关性分析，涉及临床变量。（年龄范围，18-26岁;平均[标准差]智商，99.3 [18.1]）和20名年龄和智商匹配的对照组。与对照组相比，孤独症患者全脑5-羟色胺转运体结合率显著降低（P
Context: Autism is a neurodevelopmental disorder that is characterized by repetitive and/or obsessive interests and behavior and by deficits in sociability and communication. Although its neurobiological underpinnings are postulated to lie in abnormalities of the serotoninergic and dopaminergic systems, the details remain unknown.Objective: To determine the occurrence of changes in the binding of serotonin and dopamine transporters, which are highly selective markers for their respective neuronal systems.Design: Using positron emission tomography, we measured the binding of brain serotonin and dopamine transporters in each individual with the radioligands carbon 11 (C-11)-labeled trans-1,2,3,5,6,10-beta-hexahydro-6-[4(methylthio)phenyl]pyrrolo-[2,1-a]isoquinoline ([C-11](+) McN-5652) and 2 beta-carbomethoxy-3-beta-(4-fluorophenyl) tropane ([C-11]WIN-35,428), respectively. Statistical parametric mapping was used for between-subject analysis and within-subject correlation analysis with respect to clinical variables.Setting: Participants recruited from the community.Participants: Twenty men (age range, 18-26 years; mean [SD] IQ, 99.3 [18.1]) with autism and 20 age-and IQ-matched control subjects.Results: Serotonin transporter binding was significantly lower throughout the brain in autistic individuals compared with controls (P