DUB-le vision: snapshots of the proteasome during substrate processing.
DUB-le vision: snapshots of the proteasome during substrate processing.
复制标题
DUB-le 视觉：底物处理过程中蛋白酶体的快照。
DOI：
10.1016/j.tibs.2022.07.007
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发表时间：
2022
影响因子：
13.8
通讯作者：
Hanna,John
中科院分区：
文献类型：
--
作者：
Schnell,HelenaM;Hanna,John
通过小蛋白泛素的共价修饰可以靶向蛋白质以被蛋白酶体破坏，但是泛素信号本身被回收。令人惊讶的是，蛋白酶体含有三种不同的去泛素化酶（DUB）。Zhang和Zou等人最近的工作揭示了这些酶之一Usp 14如何调节蛋白酶体以及如何受蛋白酶体调节。
Covalent modification by the small protein ubiquitin can target proteins for destruction by the proteasome, but the ubiquitin signal itself is recycled. Surprisingly, proteasomes contain three different deubiquitinating enzymes (DUBs). Recent work by Zhang and Zou et al. reveals how one of these enzymes, Usp14, regulates, and is regulated by, the proteasome.