Overview of BCL-2 Family Proteins and Therapeutic Potentials
Overview of BCL-2 Family Proteins and Therapeutic Potentials
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DOI：
10.1007/978-1-4939-8861-7_1
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发表时间：
2019-01-01
期刊：
影响因子：
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通讯作者：
Hardwick, J. Marie
中科院分区：
文献类型：
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作者：
Huska, Jason D.;Lamb, Heather M.;Hardwick, J. Marie
BCL-2家族蛋白在调节细胞凋亡的网络中相互作用。BH 3氨基酸序列基序用于将该聚集蛋白质家族结合在一起，无论是字面上还是象征性的。BH 3基序存在于抗凋亡和促凋亡BCL-2同源物中，并且存在于通常附加到BCL-2家族的一组单独的不相关的仅BH 3蛋白中。含BH 3的螺旋介导它们的许多物理相互作用以确定细胞死亡与存活，从而导致BH 3模拟物作为治疗剂的发展。在这里，我们提供了BCL-2家族相互作用的概述，它们在健康和疾病中的相关性，以及在治疗上调节它们相互作用的进展。
BCL-2 family proteins interact in a network that regulates apoptosis. The BH3 amino acid sequence motif serves to bind together this conglomerate protein family, both literally and figuratively. BH3 motifs are present in antiapoptotic and proapoptotic BCL-2 homologs, and in a separate group of unrelated BH3-only proteins often appended to the BCL-2 family. BH3-containing helices mediate many of their physical interactions to determine cell death versus survival, leading to the development of BH3 mimetics as therapeutics. Here we provide an overview of BCL-2 family interactions, their relevance in health and disease, and the progress toward regulating their interactions therapeutically.