Altered information flow and microstructure abnormalities of visual cortex in normal-tension glaucoma: Evidence from resting-state fMRI and DKI
Altered information flow and microstructure abnormalities of visual cortex in normal-tension glaucoma: Evidence from resting-state fMRI and DKI
复制标题
正常眼压性青光眼中视觉皮层的信息流改变和微观结构异常：来自静息态 fMRI 和 DKI 的证据
DOI：
10.1016/j.brainres.2020.146874
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发表时间：
2020-08-15
期刊：
影响因子：
2.9
通讯作者：
Xian, Junfang
中科院分区：
文献类型：
--
作者：
Li, Ting;Qu, Xiaoxia;Xian, Junfang
正常眼压性青光眼（Normal tension glaucoma，NTG）是一种累及多个脑区的神经退行性疾病，其发病机制尚不清楚。本研究的目的是探讨NTG的脑结构损伤和功能重组之间的相关性，使用静息态功能MRI和弥散峰度成像（DKI）数据采集26例NTG患者和24名对照组。采用格兰杰因果关系分析（GCA）计算视觉皮层与整个大脑之间的有效连通性（EC）来反映信息流。提取视皮层DKI的各向异性分数（FA）、平均峰度（MK）、轴向峰度（AK）和径向峰度（RK）来评估结构损伤。在双侧BA 17、BA 18和BA 19中检测到显微结构异常。NTG患者从BA 17到高级视皮层的EC显著降低，从高级视皮层到BA 17的EC显著增加。从BA 17到后扣带皮层（PCC）和从PCC到BA 17的EC均显著增加，而从右侧BA 18和BA 19到PCC的EC显著减少。BA 17和BA 17/BA 19与体感皮层之间的EC减少。BA 17和BA 18细胞的微结构损伤与几种异常内皮细胞有明显的相关性。总之，NTG导致视觉皮层和其他脑区之间的信息流重组，这与脑微结构损伤一致。
Normal tension glaucoma (NTG) is a neurodegenerative disease involves multiple brain areas, but the mechanism remains unclear. The aim of this study is to investigate the correlation between structural injury and functional reorganization in the brain of NTG, using resting-state functional MRI and diffusion kurtosis imaging (DKI) data acquired for 26 NTG patients and 24 control subjects. Granger causality analysis (GCA) was used to calculate the effective connectivity (EC) between visual cortices and the whole brain to reflect the information flow. The fractional anisotropy (FA), mean kurtosis (MK), axial kurtosis (AK), and radial kurtosis (RK) derived from DKI of visual cortices were extracted to evaluate structural injury. Microstructural abnormalities were detected in bilateral BA17, BA18, and BA19. NTG patients showed significantly decreased EC from BA17 to higher visual cortices and increase EC from higher visual cortices to BA17. The EC from BA17 to posterior cingulate cortex (PCC) and from PCC to BA17 both significantly increased, while the EC from right BA18 and BA19 to PCC significantly decreased. Decreased EC between somatosensory cortex and BA17, as well as the decreased ECs between supramarginal gyrus (SMA) and BA17/BA19 were detected. Several abnormal ECs were significantly correlated with microstructural injuries of BA17 and BA18. In conclusion, NTG causes reorganization of information flows among visual cortices and other brain areas, which is consistent with brain microstructural injury.