Identification of central sites involved in butorphanol-induced feeding in rats
Identification of central sites involved in butorphanol-induced feeding in rats
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DOI：
10.1016/s0006-8993(01)02322-8
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发表时间：
2001-07-13
期刊：
影响因子：
2.9
通讯作者：
Levine, AS
中科院分区：
文献类型：
--
作者：
Kim, EM;Shi, Q;Levine, AS
布托啡诺(BT)是一种混合的kappa和mu型阿片受体激动剂，可诱导大鼠摄取大量食物。外周注射Bt似乎比脑室内注射更有效地增加食物摄入量。进一步阐明BT对消费行为影响的本质。我们研究了在皮下注射Bt 4 mg/kg体重后，与摄食相关的大脑区域表现出增强的c-Fos免疫反应(IR)，该剂量已知能诱导最大的食欲反应。我们还评估了将Bt直接注射到由外周Bt注射激活的前脑区域是否会影响食物摄入量。外周给予BT可在下丘脑室旁核(PVN)、杏仁中央核(CEA)和孤束核(NTS)诱导c-Fos-IR。而CEA中注入Bt 0.1~30µg，1、2、4h摄食量无明显增加。只有最大剂量的Bt(30杯)注入PVN：增加摄食。这些结果表明，PVN、CEA和NTS介导了外周注射Bt的效应。PVN或CEA可能不是Bt立即采取行动的主要目标部位。爱思唯尔科学公司出版。
Butorphanol (BT), a mixed kappa- and mu -opioid receptor agonist, induces vigorous food intake in rats. Peripheral injection of BT seems to increase food intake more effectively than intracerebroventricular administration. To further elucidate the nature of BT's influence on consummatory behavior. we examined which feeding-related brain areas exhibit increased c-Fos immunoreactivity (IR) following subcutaneous injection of 4 mg/kg body weight BT, a dose known to induce a maximal orexigenic response. We also evaluated whether direct administration of BT into the forebrain regions activated by peripheral BT injection affects food intake. Peripheral BT administration induced c-Fos-IR in the hypothalamic paraventricular nucleus (PVN), central nucleus of the amygdala (CeA), and nucleus of the solitary tract (NTS). However, 0.1-30 mug BT infused into the CeA, failed mo increase food intake 1, 2, and 4 h after injection. Only the highest dose of BT (30 mug) injected into the PVN: increased feeding. These results suggest that the PVN, CeA, and NTS mediate the effects of peripherally-injected BT. The PVN or CeA are probably not the main target sites of immediate BT action. Published by Elsevier Science B.V.