Negative feedback and adaptive resistance to the targeted therapy of cancer.
Negative feedback and adaptive resistance to the targeted therapy of cancer.
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DOI：
10.1158/2159-8290.cd-12-0018
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发表时间：
2012-04
期刊：
影响因子：
28.2
通讯作者：
Chandarlapaty S
中科院分区：
文献类型：
--
作者：
Chandarlapaty S
Mutational activation of growth factor signaling pathways is commonly observed and often necessary for oncogenic transformation. Under physiologic conditions, these pathways are subject to tight regulation via negative feedback which limits the extent and duration of signaling events after physiologic stimulation. Until recently, the role of these negative feedback pathways in oncogene driven cancers has been poorly understood. In this review, I will discuss the evidence for the existence and relevance of negative feedback pathways within oncogenic signaling networks, the selective advantages such feedback pathways may confer and the effects such feedback might have upon therapies aimed at inhibiting oncogenic signaling.
