Magnetic localization of neuronal activity in the human brain.
Magnetic localization of neuronal activity in the human brain.
复制标题
人脑神经元活动的磁定位。
DOI：
10.1073/pnas.85.22.8732
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发表时间：
1988
影响因子：
11.1
通讯作者：
Llinás,R
中科院分区：
文献类型：
--
作者：
Yamamoto,T;Williamson,SJ;Kaufman,L;Nicholson,C;Llinás,R
已经评估了在头皮上的14个位置同时监测颅外磁场的低温系统的性能，以确定神经元活动可以定位在人脑内的准确性。最初，测量是在两个模型系统上进行的，一个是充满盐水的有机玻璃球，另一个是头骨模型。在磁场强度类似于人脑的情况下，测量和分析程序表明，对于表面下3厘米的电流偶极子，位置精度优于3毫米。随后，在三个人类受试者中获得了听觉短纯音刺激发作后100 ms出现的磁场模式的测量结果。代表大脑活跃神经元中细胞内离子电流的电流偶极子的位置以3 mm的精度被确定为在形成个体受试者的侧裂底部的皮质内，与从磁共振图像确定的Heschl脑回紧密对应。将传感器放置在适当的位置，可以在不移动记录仪器的情况下获得不同音调频率的神经源的位置。适应人类听觉皮层的活动，显示出长期的功能与范式，比较响应幅度随机提出的三个音调。
The performance of a cryogenic system that monitors the extracranial magnetic field simultaneously at 14 positions over the scalp has been evaluated to determine the accuracy with which neuronal activity can be located within the human brain. Initially, measurements were implemented on two model systems, a lucite sphere filled with saline and a model skull. With a magnetic field strength similar to that of a human brain, the measurement and analysis procedures demonstrated a position accuracy better than 3 mm, for a current dipole 3 cm beneath the surface. Subsequently, measurements of the magnetic field pattern appearing 100 ms after the onset of an auditory tone-burst stimulus were obtained in three human subjects. The location of the current dipole representing intracellular ionic current in active neurons of the brain was determined, with 3-mm accuracy, to be within the cortex forming the floor of the Sylvian fissure of the individual subjects, corresponding closely to the Heschl gyrus as determined from magnetic resonance images. With the sensors placed at appropriate positions, the locations of neuronal sources for different tone frequencies could be obtained without moving the recording instrument. Adaptation of activity in human auditory cortex was shown to reveal long-term features with a paradigm that compared response amplitudes for three tones randomly presented.