Aberrant expression of CHFR in malignant peripheral nerve sheath tumors
Aberrant expression of CHFR in malignant peripheral nerve sheath tumors
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DOI：
10.1038/modpathol.3800548
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发表时间：
2006-04-01
期刊：
影响因子：
7.5
通讯作者：
Tsuneyoshi, M
中科院分区：
文献类型：
--
作者：
Kobayashi, C;Oda, Y;Tsuneyoshi, M
有丝分裂检查点在有丝分裂前维持基因组的完整性。大量的观察表明，有丝分裂异常导致染色体不稳定和非整倍体。在MPNST中，已经描述了显示数量和结构畸变的复杂核型。“叉头相关结构域和环指的检查点”（CHFR）最近被确定为定义一个新的早期有丝分裂检查点。应用免疫组化和分子生物学方法检测了96例MPNST中CHFR的表达。我们发现（分数，
Mitotic checkpoint maintains genomic integrity before mitosis. Numerous observations have suggested that mitotic abnormalities produce chromosomal instability and aneuploidy. In MPNST, complex karyotypes showing numerical and structural aberrations have been described. 'Checkpoint with forkhead-associated domain and ring finger' (CHFR) was recently identified as defining a new early mitotic checkpoint. We examined the expression of CHFR in 96 cases of MPNST by immunohistochemical and molecular methods. We found reduced (score,