Effect of sex hormones on bone in primary osteoporosis.
Effect of sex hormones on bone in primary osteoporosis.
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性激素对原发性骨质疏松症骨的影响。
DOI：
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发表时间：
1969
影响因子：
15.9
通讯作者：
F. T. Maher
中科院分区：
文献类型：
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作者：
B. Riggs;J. Jowsey;P. Kelly;J. D. Jones;F. T. Maher
研究了性激素对12例骨质疏松症患者骨组织的影响。在11名绝经后妇女和1名性能男性接受雌激素和睾酮治疗前后，通过定量显微放射学对髂嵴活检样本进行了骨形成和吸收表面的测定。治疗前，除1例患者外，其余患者骨吸收均大于正常，骨形成正常。治疗后，所有患者骨吸收均降至正常范围，骨形成无明显变化。生化研究显示血清钙、磷、碱性磷酸酶水平和尿钙、羟脯氨酸排泄显著降低。这些变化被认为是激素对骨骼作用的结果。数据表明，性激素在骨质疏松症中的主要作用是抑制骨吸收。
The effect of sex hormones on bone tissue was studied in 12 osteoporotic patients. Surfaces of bone undergoing formation and resorption were determined by quantitative microradiography of iliac crest biopsy samples before and after treatment with estrogens in 11 postmenopausal women and with testosterone in one gonadally competent man. Before treatment, bone resorption was greater than normal in all but one patient and bone formation was normal. After treatment, bone resorption decreased to within the normal range in all patients, and bone formation did not change significantly. Biochemical studies showed significant decreases in serum calcium, phosphorus, and alkaline phosphatase levels and in urinary excretion of calcium and hydroxyproline. These changes are believed to be the consequence of the effect of the hormones on bone. The data indicate that the major effect of sex hormones in osteoporosis is an inhibition of bone resorption.