Imaging Findings After Fat Graft Interposition in an Injured Growth Plate: An Experimental Study in Rabbits
Imaging Findings After Fat Graft Interposition in an Injured Growth Plate: An Experimental Study in Rabbits
复制标题
受伤的生长板中脂肪移植物介入后的影像学结果：兔子的实验研究
DOI：
10.1097/01.rli.0000084254.92161.9c
复制
发表时间：
2003
影响因子：
6.7
通讯作者：
K. Yeon
中科院分区：
文献类型：
--
作者：
J. Cheon;In;C. Kim;W. Kim;W. Yoo;I. Choi;K. Yeon
基本原理和目标：评估实验诱导的生长板损伤中脂肪移植物插入的磁共振（MR）特征，将这些特征与组织学结果相关联，并比较脂肪移植和非脂肪移植生长板损伤的生长障碍。方法：20只骨骼未成熟兔建立生长板损伤模型。 14 只兔子的胫骨近端内侧半部出现双侧生长板缺损。右侧胫骨缺损处用自体脂肪填充；左胫骨是空的。在另外 6 只兔子中，在右胫骨中插入脂肪移植物（n = 3）或不插入脂肪移植物（n = 3），造成单侧生长板缺损。术后 2、4 和 12 周使用 1.5-T MR 装置进行 MR 成像。在冠状面获得T1加权图像、T2加权图像、梯度回波图像和对比增强T1加权图像。作者评估了有或没有脂肪移植的生长板缺陷以及剩余生长板的 MR 特征。将移植胫骨的长度和角度与非脂肪移植胫骨进行比较。结果：术后2周，移植区T1加权成像显示低信号强度与高信号强度混合（71%）。两周时，对照动物的大部分生长板缺陷在所有图像序列中均显示出低信号强度。 4 周时，大部分移植区域在 T2 加权成像上显示出低信号强度。 4 周时，15% 的移植胫骨和 62% 的对照动物出现骨桥。在梯度回波图像上，移植的胫骨中保留了剩余生长板的高信号强度，但在对照动物中，这种信号在术后 4 周变得不可见。第 12 周时，移植胫骨和对照动物的所有图像序列上的大部分生长板缺损区域均变为等信号。组织学上，脂肪移植区域被纤维结缔组织取代，形成薄的骨小梁。对照动物的生长板缺陷充满成熟的脂肪骨髓并形成骨小梁。术后4周和12周时，脂肪移植胫骨的胫骨内翻角和内侧长度有显着差异。结论：MR成像有助于评估脂肪移植术后生长板的修饰及后续变化。脂肪移植物介入可以减少生长板损伤中的生长障碍。
Rationale and Objectives:To assess the magnetic resonance (MR) features of fat graft interposition in experimentally induced growth plate injury, to correlate these features with histologic findings, and to compare the growth disturbances of fat-grafted and nonfat-grafted growth plate injuries. Methods:The growth plate injury model was created in 20 skeletally immature rabbits. In 14 rabbits, a bilateral growth plate defect was made in the medial half of the proximal tibia. The defect of the right tibia was filled with autologous fat; the left tibia was left empty. In another 6 rabbits, a unilateral growth plate defect was created with (n = 3) or without (n = 3) fat graft interposition in the right tibia. MR imaging was performed at 2, 4, and 12 weeks postoperatively using a 1.5-T MR unit. T1-weighted images, T2-weighted images, gradient echo images, and contrast-enhanced T1-weighted images were obtained in the coronal plane. The authors evaluated the MR features of the growth plate defects with or without fat graft, and the remaining growth plate. The length and angulation of the grafted tibia were compared with those of the nonfat-grafted tibia. Results:At 2 weeks postoperatively, the grafted area showed low signal intensity mixed with high signal intensity (71%) on T1-weighted imaging. At 2 weeks, most of the growth plate defect in the control animals showed low signal intensity in all image sequences. At 4 weeks, most of the grafted area showed low signal intensity on T2-weighted imaging. A bone bridge was revealed in 15% of the grafted tibia and in 62% of the control animals at 4 weeks. On gradient echo images, high signal intensity of the remaining growth plate was preserved in grafted tibias, but in the control animals this became invisible 4 weeks postoperatively. At 12 weeks, most of growth plate defect area became isointense on all image sequences in grafted tibia and in the control animals. Histologically, the fat-grafted area was replaced by fibrous connective tissues with thin, trabecular bone formation. Growth plate defects of the control animals were filled with mature fatty marrow with trabecular bone formation. The varus angle and medial length of the tibia were significantly different between fat-grafted tibias at 4 weeks and 12 weeks postoperatively. Conclusion:MR imaging was helpful for evaluating growth plate modifications and subsequent changes after fat graft interposition. Fat graft interposition had a role in reducing growth disturbance in growth plate injury.