(±)3,4-methylenedioxymethamphetamine, d-amphetamine, and cocaine impair delayed matching-to-sample performance by an increase in susceptibility to proactive interference
(±)3,4-methylenedioxymethamphetamine, d-amphetamine, and cocaine impair delayed matching-to-sample performance by an increase in susceptibility to proactive interference
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DOI：
10.1037/0735-7044.119.2.455
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发表时间：
2005-04-01
影响因子：
1.9
通讯作者：
Schenk, S
中科院分区：
文献类型：
--
作者：
Harper, DN;Wisnewski, R;Schenk, S
本研究比较了（+/-）3，4-亚甲二氧基甲基苯丙胺、d-苯丙胺和可卡因对大鼠在延迟匹配样本程序中表现的影响，使用各种表现指数来确定工作记忆任务损伤出现的机制。所有3种药物都产生了准确性的整体延迟独立性下降，而不是遗忘率的延迟依赖性增加。这种损害是由于当前试验选择反应随着药物剂量增加而逐渐受到前一次试验中反应的影响。因此，所有3种药物在记忆任务表现方面产生了定性相似的中断，其最佳特征是由前摄干扰源引起的损害。
This study compared the effects of (+/-)3,4-methylenedioxymethamphetamine, d-amphetamine, and cocaine on performance of rats in a delayed matching-to-sample procedure using a variety of indices of performance to determine the mechanism by which working memory task impairments arise. All 3 drugs produced an overall delay- independent decrease in accuracy rather than a delay-dependent increase in the rate of forgetting. This impairment arose as a result of current-trial choice responses being progressively more affected by responses made in the immediately preceding trial as drug dose increased. Therefore, all 3 drugs produced qualitatively similar disruptions in memory task performance best characterized as an impairment arising from proactive sources of interference.