Interferon-α significantly reduces cerebrospinal fluid CD4 cell subsets in HAM/TSP
Interferon-α significantly reduces cerebrospinal fluid CD4 cell subsets in HAM/TSP
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DOI：
10.1016/s0165-5728(03)00219-4
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发表时间：
2003-08-01
影响因子：
3.3
通讯作者：
Itoyama, Y
中科院分区：
文献类型：
--
作者：
Feng, J;Misu, T;Itoyama, Y
我们，第一次，分析了T细胞和自然杀伤（NK）细胞亚群在脑脊液（CSF）中的9例人类T淋巴细胞病毒1型（HTLV-1）相关的脊髓病/热带痉挛性截瘫（HAM/TSP）与干扰素-α（IFN-α）治疗。治疗后CSF中CD 4/CD 8比值明显降低，主要是由于CD 4+细胞，尤其是CD 25 + CD 4和CD 45 RO + CD 4细胞亚群明显减少所致。同时，CSF中的NK、天然T和NKT细胞亚群保持不变。在这项小规模研究中，没有CSF淋巴细胞亚群与IFN-α的临床疗效显著相关，应分析更多患者以确定联系。(C)2003 Elsevier B. V.保留所有权利
We, for the first time, analyzed T cell and natural killer (NK) cell subsets in the cerebrospinal fluid (CSF) in nine patients with human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) treated with interferon-alpha (IFN-alpha). The CD4/CD8 ratio in CSF was significantly lower after the therapy, which is mainly attributable to the significant reduction in CD4+ cells, especially CD25 + CD4 and CD45RO + CD4 cell subsets. Meanwhile, NK, natural T and NKT cell subsets in the CSF remained unchanged. There was no CSF lymphocyte subset significantly associated with the clinical efficacy of IFN-alpha in this small-scale study, and more patients should be analyzed to ascertain the link. (C) 2003 Elsevier B.V. All rights reserved