Editorial overview – Nanocatalysis
Editorial overview – Nanocatalysis
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编辑概述 – 纳米催化
DOI：
10.1016/j.cogsc.2023.100814
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发表时间：
2023
影响因子：
9.3
通讯作者：
Handa, Sachin
中科院分区：
文献类型：
--
作者：
Leahy, David K.;Handa, Sachin
§ Biohaven Ltd，215 Church Street，New Haven，Connecticut，06510，United States <$路易斯维尔大学化学系，2320 S. Brook Street，Louisville，肯塔基州40292，United States* 电子邮件：大卫. Leahy@ biohavenpharma. com; sachin. handa@ louisville.纳米技术彻底改变了许多科学领域，包括可持续催化。它为可持续和更绿色的有机合成做出了独特的贡献，能够在更绿色的介质中实现强大的催化作用，包括水和其他可持续溶剂。1-4为了突出该领域的最新进展，我们组织了一个关于纳米催化的特刊。在这个专题中，我们涵盖了使用地球上丰富的金属和低负载的贵金属，可持续介质中的混合金属纳米催化，生物催化和电子纳米催化的高效纳米催化。我们邀请了明确展示上述技术的发现，开发和应用的贡献，其中明确阐述了与可持续发展相关的优点。所有手稿都通过了严格的同行评审，遵循Curr的政策。Opin.绿色支持。许多高需求的有机分子需要更好的合成方法，生物催化和纳米催化为满足可持续的供需挑战做出了重大贡献。同样，非典型氨基酸（ncAA）在药物发现中的应用的持续增长需要其高效，可持续和可规模化的生产，从而获得新的化学实体。与此相关，Arnold、Alfonzo和Das描述了ncAA的生物催化合成。这些氨基酸融合了蛋白质氨基酸的构象行为和天然相互作用与非天然化学基序，并已被证明在开发现代治疗方法中有价值。在这篇小型综述中，作者扩展了用天然酶合成ncAA的生物催化剂库。有关更多详细信息，请参阅：https：//doi. org/10.1016/j. cogsc. 2022.100701.同样的特刊涵盖了可持续反应介质中的纳米颗粒，如水和低共熔溶剂。水在更好和更清洁的化学方面可以提供很多东西。然而，其作为反应介质的用途尚未达到其全部潜力。利用区室化效应，胶束催化在水中实现化学。Lipshutz及其同事展示了含铁ppm级钯纳米颗粒的合成和应用。在本文中，作者只介绍了他们实验室的工作，尽管其他几位研究人员对同一领域做出了重大贡献。作者描述了由连接的铁ppm钯纳米颗粒催化的可持续的Suzuki-Miyaura、Sonogashira、Mizoroki-Heck和Negishi偶联。此外，还讨论了水中硝基还原和点击反应。更多细节可以在文章中找到：https：//doi. org/10.1016/j. cogsc. 2022.100686.沿着同样的思路，Gallou和他的同事们展示了纳米催化剂在制药工业中的应用。在描述纳米分析时，作者批判性地展示了
§ Biohaven Ltd, 215 Church Street, New Haven, Connecticut, 06510, United States† Department of Chemistry, University of Louisville, 2320 S. Brook Street, Louisville, Kentucky 40292, United States* Email: david. leahy@ biohavenpharma. com; sachin. handa@ louisville. edu Nanotechnology has revolutionized many areas of science, including sustainable catalysis. It has uniquely contributed to sustainable and greener organic synthesis, enabling powerful catalysis in greener media, including water and other sustainable solvents. 1-4 To highlight the recent advancements in the field, we organized a special issue on nanocatalysis. In this thematic issue, we covered efficient nanocatalysis using earth-abundant metals and low loading of precious metals, hybrid metal nanocatalysis in sustainable media, biocatalysis, and electronanocatalysis. We invited contributions that clearly demonstrate the discovery, development, and application of the above technologies, where their merit related to sustainably is clearly articulated. All manuscripts passed through rigorous peer review, following the policies of Curr. Opin. Green Sustain. Chem.Many organic molecules in high demand require better synthetic methods, and biocatalysis and nanocatalysis have contributed significantly to meeting sustainable demand-supply challenges. Likewise, the continued growth in the application of noncanonical amino acids (ncAAs) in drug discovery necessitates their efficient, sustainable, and scalable production, granting access to new chemical entities. Related to this topic, Arnold, Alfonzo, and Das describe the biocatalytic synthesis of ncAAs. These amino acids merge the conformational behavior and native interactions of proteinogenic amino acids with nonnative chemical motifs and have proven valuable in developing modern therapeutics. In this mini review, the authors extended the biocatalyst arsenal for synthesizing ncAAs with natural enzymes. For more details, see: https://doi. org/10.1016/j. cogsc. 2022.100701. The same special issue covers nanoparticles in sustainable reaction media, such as water and deep eutectic solvents. Water has a lot to offer in terms of better and cleaner chemistry. However, its usage as a reaction medium has not reached its full potential. Harnessing the compartmentalization effect, micellar catalysis enabled chemistry in water. Lipshutz and co-workers showcased the synthesis and applications of nanoparticles of iron-containing ppm levels of palladium. In this article, the authors only covered the work from their lab, although several other researchers have contributed significantly to the same field. The authors have described the sustainable Suzuki–Miyaura, Sonogashira, Mizoroki–Heck, and Negishi couplings catalyzed by ligated iron ppm palladium nanoparticles. In addition, nitro group reductions and click reactions in water are also discussed. More details can be found in the arti-cle: https://doi. org/10.1016/j. cogsc. 2022.100686. Along the same lines, Gallou and co-workers have showcased nanocatal-ysis in the pharmaceutical industry. While describing nanoca-talysis, the authors have critically showcased the use of