Interaction of T cells with APCs: the serial encounter model
Interaction of T cells with APCs: the serial encounter model
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DOI：
10.1016/s1471-4906(01)01869-5
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发表时间：
2001-04-01
影响因子：
16.8
通讯作者：
Gunzer, M
中科院分区：
文献类型：
--
作者：
Friedl, P;Gunzer, M
原发性免疫应答由抗原特异性T细胞和专职抗原呈递细胞（APC）的特异性物理相互作用启动。生产性相互作用可以是一个动态过程，其将物理T细胞结合APC与APC表面的剧烈爬行和扫描相结合，导致信号诱导。在T细胞脱离后，随后与相同或相邻树突状细胞（DC）的迁移接触允许连续信号和相互作用时间的积累。在这里，我们开发了一个T细胞激活的系列遭遇模型，并讨论了多个信号的总和如何提供一个有效的策略来控制正在进行的免疫反应。
Primary immune responses are initiated by specific physical interaction of antigen-specific T cells and professional antigen-presenting cells (APCs). Productive interactions can be a dynamic process that combines physical T-cell binding to APCs with vigorous crawling across and scanning of the APC surface, resulting in signal induction. After T-cell detachment, subsequent migratory contacts to the same or neighboring dendritic cells (DCs) allow the accumulation of sequential signals and interaction time. Here, we develop a serial encounter model of T-cell activation and discuss how the summation of multiple signals provides an efficient strategy to control an ongoing immune response.