ANTAGONISM OF THE EFFECTS OF THE HALLUCINOGEN DOM AND THE PURPORTED 5-HT AGONIST QUIPAZINE BY 5-HT2 ANTAGONISTS
ANTAGONISM OF THE EFFECTS OF THE HALLUCINOGEN DOM AND THE PURPORTED 5-HT AGONIST QUIPAZINE BY 5-HT2 ANTAGONISTS
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DOI：
10.1016/0014-2999(83)90464-8
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发表时间：
1983-01-01
影响因子：
5
通讯作者：
ROSECRANS, JA
中科院分区：
文献类型：
--
作者：
GLENNON, RA;YOUNG, R;ROSECRANS, JA
在二水平操作选择任务中，训练大鼠区分1.0 mg/kg 1-（2,5-二甲氧基-4-甲基苯基）-2-氨基丙烷（DOM）和生理盐水，给药剂量为美斯卡林、LSD、5-甲氧基-N，N-二甲基色胺（5- ome DMT）、喹嗪、TFMPP [N-（3-三氟甲基苯基）哌嗪]和RU-24969[5-甲氧基-3-（1,2,5,6-四氢吡啶基）吲哚]。dom -刺激扩展到3种致幻剂和喹帕嗪，但不包括所谓的5 -羟色胺激动剂TFMPP或RU-24969。用5-HT2拮抗剂酮色林和哌烯酮预处理动物可拮抗DOM的作用。哌酮阻断了dom刺激对美斯卡林、LSD、5-OMe DMT和喹帕嗪的推广。DOM （DOM刺激泛化发生的三种致幻剂）和喹帕嗪的区别刺激作用可能涉及那些被氚化酮色胺标记的5-羟色胺受体亚群（即5-HT2位点）。
Rats trained to discriminate 1.0 mg/kg of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) from saline in a 2-lever operant choice task were administered doses of mescaline, LSD, 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT), quipazine, TFMPP [N-(3-trifluoromethylphenyl)piperazine] and RU-24969 [5-methoxy-3-(1,2,5,6-tetrahydropyridinyl)indole]. The DOM-stimulus generalized to the 3 hallucinogenic agents and to quipazine, but not to the purported serotonin agonists TFMPP or RU-24969. Pretreatment of the animals with the 5-HT2 antagonists ketanserin and pirenperone antagonized the effect produced by DOM. Pirenperone blocked DOM-stimulus generalization to mescaline, LSD, 5-OMe DMT and quipazine. The discriminative stimulus effects of DOM, the 3 hallucinogenic agents to which DOM-stimulus generalization occurred and quipazine, may involve those sub-populations of serotonin receptors that are labeled by tritiated ketanserin (i.e., 5-HT2 sites).