Depression Severity, but Not Cognitive Impairment or Frailty, is Associated with Disability in Late-Life Depression.
Depression Severity, but Not Cognitive Impairment or Frailty, is Associated with Disability in Late-Life Depression.
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DOI：
10.1080/07317115.2019.1699882
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发表时间：
2020-07
影响因子：
2.8
通讯作者：
Mackin, R. Scott
中科院分区：
文献类型：
--
作者：
Morin, Ruth T.;Insel, Philip;Bickford, David;Nelson, Craig;Mackin, R. Scott
评估老年抑郁症(LLD)患者认知障碍与残疾的关系，包括抑郁症的严重程度和脆弱程度。分析了78名患有LLD和非痴呆症的社区老年人(年龄M=71.9；SD=6.1)的数据。认知功能是使用综合神经心理组合进行评估的。使用17项汉密尔顿抑郁评定量表(HDRS；截止≥15)测量抑郁严重程度。通过几项运动测试来评估其脆弱程度。世界卫生组织残疾评估表(WHO-DAS)衡量了残疾状况。采用线性回归分析来确定认知、脆弱和抑郁严重程度与残疾的关系。认知受损测试的平均次数为2.0次(SD=1.9)，28.2%的参与者没有出现受损分数。参与者平均报告的抑郁严重程度为17.3(SD=3.6)，残疾总分为15.1(SD=6.9)。回归模型可以解释残疾变量的25.1%，只有抑郁严重程度才能显著预测残疾状态。在这个样本中，认知损害的负担和虚弱并不能预测残疾。在这个样本中，只有抑郁症的严重程度与残疾增加有关。这些发现对LLD的干预有一定的意义，因为抑郁症的严重程度可能代表着一个更具可变性的残疾风险因素。
Assess the relationship of cognitive impairment to disability, accounting for depression severity and frailty, among older adults with late life depression (LLD). Data were analyzed from 78 community-dwelling older adults with LLD and without dementia (age M=71.9; SD=6.1). Cognitive functioning was assessed using a comprehensive neuropsychological battery. Depression severity was measured using the 17-item Hamilton Depression Rating Scale (HDRS; cutoff ≥15). Frailty was assessed using several motor tests. The World Health Organization Disability Assessment Schedule (WHO-DAS) measured disability status. A linear regression analysis was performed to identify relationships of cognition, frailty and depression severity with disability. The average number of impaired cognitive tests was 2.0 (SD=1.9), with 28.2% of participants showing no impaired scores. On average participants reported depression severity of 17.3 (SD=3.6), and disability total score of 15.1 (SD=6.9). The regression model accounted for 25.1% of the variance in disability, with only depression severity significantly predicting disability status. Burden of cognitive impairment and frailty were not predictive of disability in this sample. In this sample, only depression severity was associated with increased disability. These findings have implications for intervention in LLD, as depression severity may represent a more modifiable risk factor for disability.
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DOI：
10.1016/s0003-9993(97)90005-8
发表时间：
1997-01-01
影响因子：
4.3
作者：
Bohannon, RW
通讯作者：
Bohannon, RW
影响因子：
4
作者：
Iwasa, Hajime;Gondo, Yasuyuki;Suzuki, Takao
通讯作者：
Suzuki, Takao
影响因子：
2.8
作者：
Gould, Christine E.;Huh, J. W. Terri;Tenover, J. Lisa
通讯作者：
Tenover, J. Lisa
影响因子：
7.2
作者：
Kiosses, DN;Alexopoulos, GS
通讯作者：
Alexopoulos, GS
影响因子：
7.2
作者：
Mackin, R. Scott;Nelson, J. Craig;Delucchi, Kevin L.;Raue, Patrick J.;Satre, Derek D.;Kiosses, Dimitris N.;Alexopoulos, George S.;Arean, Patricia A.
通讯作者：
Arean, Patricia A.