Instrumentation and design of a frequency-domain diffuse optical tomography imager for breast cancer detection
Instrumentation and design of a frequency-domain diffuse optical tomography imager for breast cancer detection
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DOI：
10.1364/oe.1.000391
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发表时间：
1997-12-22
期刊：
影响因子：
3.8
通讯作者：
Paulsen, Keith
中科院分区：
文献类型：
--
作者：
Pogue, Brian W.;Testorf, Markus;Paulsen, Keith
详细介绍了用于乳腺癌检测的频域光学成像原型装置的仪器开发和设计。该装置采用射频强度调制的近红外光定量成像的散射和吸收系数的组织。该系统的功能组件包括一个激光二极管和一个光电倍增管，使用高精度线性平移台通过32个大芯光纤束自动多路复用。图像重建基于扩散方程的有限元解。这种用于解决光子迁移的正向问题的工具被耦合到迭代光学性质估计算法，该算法使用具有总变差最小化的Levenberg-Marquardt例程。这一发展的结果是一个自动化的频域光学成像计算机断层扫描，产生定量准确的图像的测试phantomy使用的日期。本文是一个自动频域计算机断层扫描仪的描述和表征，这是更多的定量比早期系统中使用的透照，因为强度调制信号检测和迭代图像重建的组合。(C)1997年美国光学学会
The instrument development and design of a prototype frequency-domain optical imaging device for breast cancer detection is described in detail. This device employs radio-frequency intensity modulated near-infrared light to image quantitatively both the scattering and absorption coefficients of tissue. The functioning components of the system include a laser diode and a photomultiplier tube, which are multiplexed automatically through 32 large core fiber optic bundles using high precision linear translation stages. Image reconstruction is based on a finite element solution of the diffusion equation. This tool for solving the forward problem of photon migration is coupled to an iterative optical property estimation algorithm, which uses a Levenberg-Marquardt routine with total variation minimization. The result of this development is an automated frequency-domain optical imager for computed tomography which produces quantitatively accurate images of the test phantoms used to date. This paper is a description and characterization of an automated frequency-domain computed tomography scanner, which is more quantitative than earlier systems used in diaphanography because of the combination of intensity modulated signal detection and iterative image reconstruction. (C) 1997 Optical Society of America