The Role of PPAR Ligands in Controlling Growth-Related Gene Expression and their Interaction with Lipoperoxidation Products.
The Role of PPAR Ligands in Controlling Growth-Related Gene Expression and their Interaction with Lipoperoxidation Products.
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DOI：
10.1155/2008/524671
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发表时间：
2008
期刊：
影响因子：
2.9
通讯作者：
Ferretti C
中科院分区：
文献类型：
--
作者：
Barrera G;Toaldo C;Pizzimenti S;Cerbone A;Pettazzoni P;Dianzani MU;Ferretti C
过氧化物酶体增殖物激活受体 (PPAR) 是属于核激素受体超家族的配体激活转录因子。已发现三种 PPAR 亚型（α、γ 和 β/δ）在细胞脂肪代谢中发挥多效性作用。此外，近年来，已经发现有关 PPAR 配体，特别是 PPARγ 配体表现出的抗增殖、促凋亡和促进分化活性的证据。 PPAR 配体通过 PPAR 依赖性和 PPAR 独立机制影响不同生长相关基因的表达。此外，已经描述了PPAR配体和其他分子之间的相互作用，其增强了PPAR配体的作用。在此，我们回顾 PPAR 对基因表达控制的作用，特别是 PPAR 配体对参与细胞周期、分化和凋亡调节的基因表达的影响。此外，还对 PPAR 配体和脂质过氧化的主要产物 4-羟基壬烯醛 (HNE) 之间的相互作用进行了综述。
Peroxisome proliferators-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. The three PPAR isoforms (α, γ and β/δ) have been found to play a pleiotropic role in cell fat metabolism. Furthermore, in recent years, evidence has been found regarding the antiproliferative, proapoptotic, and differentiation-promoting activities displayed by PPAR ligands, particularly by PPARγ ligands. PPAR ligands affect the expression of different growth-related genes through both PPAR-dependent and PPAR-independent mechanisms. Moreover, an interaction between PPAR ligands and other molecules which strengthen the effects of PPAR ligands has been described. Here we review the action of PPAR on the control of gene expression with particular regard to the effect of PPAR ligands on the expression of genes involved in the regulation of cell-cycle, differentiation, and apoptosis. Moreover, the interaction between PPAR ligands and 4-hydroxynonenal (HNE), the major product of the lipid peroxidation, has been reviewed.
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影响因子：
14.9
作者：
Baldán, A;Relat, J;Haro, D
通讯作者：
Haro, D
DOI：
10.1016/s0006-291x(02)00649-6
发表时间：
2002-07-12
影响因子：
3.1
作者：
Barrera, G;Pizzimenti, S;Dianzani, MU
通讯作者：
Dianzani, MU
影响因子：
13.6
作者：
Benigni, Ariela;Zoja, Carla;Remuzzi, Giuseppe
通讯作者：
Remuzzi, Giuseppe
影响因子：
3.6
作者：
Bae, MA;Song, BJ
通讯作者：
Song, BJ
影响因子：
3.5
作者：
Brouillette, C;Bossé, Y;Vohl, MC
通讯作者：
Vohl, MC