Pubertal development and onset of psychosis in childhood onset schizophrenia
Pubertal development and onset of psychosis in childhood onset schizophrenia
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DOI：
10.1016/s0165-1781(97)03062-x
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发表时间：
1997-04-18
影响因子：
11.3
通讯作者：
Rapoport, JL
中科院分区：
文献类型：
--
作者：
Frazier, JA;AlaghbandRad, J;Rapoport, JL
在这项研究中，对 12 岁时患有儿童期精神分裂症 (COS)（定义为精神病）的儿童和青少年样本的青春期发育情况进行了检查。获得了 28 名患有严重难治性 COS 的青少年（平均年龄 14.5 +/- 2.3 岁）（14 名男性，14 名女性）的发育和精神病史。还检查了精神病发病年龄与初潮和第二性征发育的关系。女孩有比男孩更早形成第二性征的趋势（P = 0.06），这与北美标准一致。男性 (N = 14) 和女性 (N = 14) 的精神病发病年龄相似。第二性征的发育年龄与女孩精神病的发病有关，但这一发现是由一个异常值驱动的。精神病的发展与初潮之间没有显着相关性。男性和女性先证者的青春期发育开始年龄与他们健康的兄弟姐妹或北美标准没有显着差异。没有证据表明该样本的第二性征早期出现。最后，对于这些非常早期发病的病例，精神病的发病与性发育指数之间没有明确的关系。 (C) 1997 爱思唯尔科学爱尔兰有限公司
In this study, pubertal development was examined for a sample of children and adolescents with childhood onset schizophrenia (COS) defined as psychosis by age 12. Developmental and psychiatric histories were obtained for 28 adolescents (mean age 14.5 +/- 2.3 years) with severe, treatment refractory COS (14 males, 14 females). Age of onset of psychosis was also examined in relation to menarche and development of secondary sex characteristics. Girls had a trend towards developing secondary sex characteristics earlier than boys (P = 0.06), consistent with North American norms. Males (N = 14) and females (N = 14) had similar age of onset of psychosis. The age of development of secondary sex characteristics was associated with onset of psychosis for girls, but this finding was driven by one outlier. There was no significant correlation between development of psychosis and menarche. Neither male nor female probands differed significantly from their well siblings or from North American norms in their age of onset of pubertal development. There was no evidence of early onset of secondary sex characteristics for this sample. Finally, there was an absence of a clear relationship between onset of psychosis and indices of sexual development for these very early onset cases. (C) 1997 Elsevier Science Ireland Ltd.