Associations between a decreased veterinary antimicrobial use and resistance in commensal Escherichia coli from Belgian livestock species (2011-2015)
Associations between a decreased veterinary antimicrobial use and resistance in commensal Escherichia coli from Belgian livestock species (2011-2015)
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DOI：
10.1016/j.prevetmed.2017.10.013
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发表时间：
2018-09-01
影响因子：
2.6
通讯作者：
Welby, Sarah
中科院分区：
文献类型：
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作者：
Callens, Benedicte;Cargnel, Mickael;Welby, Sarah
在这项研究中，探讨了抗生素使用与耐药性之间可能存在的关联，重点关注2011年至2015年期间比利时牲畜（小牛，年轻肉牛，猪和肉鸡）中的大肠杆菌。除酚类外，所有类别的抗生素使用均呈持续下降趋势。大肠埃希菌耐药性分析大肠杆菌显着降低了几个测试的抗生素在所有牲畜物种。对第3/4代头孢菌素和氟喹诺酮类药物的耐药逆转更快。除了对氯霉素和庆大霉素的抗生素耐药性以及相应抗生素类别的使用外，发现抗生素使用与耐药性之间存在中度至强烈的相关性。然而，总的抗生素使用与氯霉素耐药性呈正相关，显示了共同选择对氯霉素耐药性的潜在重要性。这些结果表明，国家抗菌药物使用减少运动对整体耐药性水平有有益的影响。不过，分析是在小数据集上进行的，在进行推断时必须小心。为了进行更详细的分析，需要动物物种水平的抗生素使用数据。
In this study the possible association between antibiotic use and resistance was explored, focusing on commensal Escherichia colt from livestock (veal calves, young beef cattle, pigs and broiler chickens) in Belgium between 2011 and 2015. A continuous decreasing trend in antibiotic use was observed for all classes, except for the phenicols. Antibiotic resistance of commensal E. coli significantly decreased for several of the tested antibiotics in all livestock species. A more rapidly reverted resistance was seen to 3th/4th generation cephalosporins and fluoroquinolones. Moderate to strong correlations between antibiotic use and resistance were found, except for antibiotic resistance to chloramphenicol and gentamicin and the use of the corresponding antibiotic class. Yet, total antibiotic use was positively correlated with chloramphenicol resistance, showing the potential importance of co-selection for chloramphenicol resistance. These results suggest that national antimicrobial usage reduction campaigns have beneficial effects on the overall resistance levels. Analyses were performed on small datasets, though, and care must be taken while making inference. For more detailed analysis, antibiotic use data at an animal species level are required.