Complexity-Building Photoinduced Cascade Involving C sp2 –C sp3 Coupling of Aromatic Amides via [2 + 2] Reactivity of ESIPT-Generated o- Azaxylylenes
Complexity-Building Photoinduced Cascade Involving C sp2 –C sp3 Coupling of Aromatic Amides via [2 + 2] Reactivity of ESIPT-Generated o- Azaxylylenes
复制标题
通过 [2 2] ESIPT 生成的邻亚二甲苯基的反应性，涉及 C sp2 →C sp3 芳香酰胺偶联的复杂性光诱导级联
DOI：
10.1021/acs.orglett.3c00092
复制
发表时间：
2023
期刊：
影响因子：
5.2
通讯作者：
Kutateladze, Andrei G.
中科院分区：
文献类型：
--
作者：
Reddy, D. Sai;Novitskiy, Ivan M.;Kutateladze, Andrei G.
通过ESIPT产生的氮杂亚甲基的前所未有的[2 + 2]反应性，获得了一种新的络合物构建光化学级联的模式，该模式提供了实验上简单的无过渡金属的芳香酰胺的分子内Csp 2-Csp 3交叉偶联。再加上简短而直接的postphotochemical修改的主要光产物，这些级联允许一个显着的步骤归一化增长的分子复杂性，同时访问多样和复杂的多杂环分子架构。
A new mode for complexity-building photochemical cascades which offers experimentally simple transition metal-free intramolecular Csp2–Csp3cross coupling of aromatic amides is attained via an unprecedented [2 + 2] reactivity of ESIPT-generated azaxylylenes. Coupled with short and straightforward postphotochemical modifications of the primary photoproducts, these cascades allow for a significant step-normalized growth of molecular complexity while accessing diverse and complex polyheterocyclic molecular architectures.