I can see where you would be: Patterns of fMRI activity reveal imagined landmarks
I can see where you would be: Patterns of fMRI activity reveal imagined landmarks
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DOI：
10.1016/j.neuroimage.2016.08.034
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发表时间：
2017-01-01
期刊：
影响因子：
5.7
通讯作者：
Galati, Gaspare
中科院分区：
文献类型：
--
作者：
Boccia, Maddalena;Sulpizio, Valentina;Galati, Gaspare
当从记忆中获取感知信息时，视觉心理意象就会产生，从而产生“用心灵的眼睛看”的体验。人类腹侧视觉流中不同内容相关的大脑区域在视觉心理意象过程中被激活，类似于视觉感知过程中发生的情况。这些区域内的神经模式（但不是早期视觉皮层）在意象和感知过程中是相似的，这表明，在缺乏知觉刺激的情况下，内容依赖的大脑区域能够重新实例化特定的神经模式，从而实现心理意象。然而，目前尚不清楚这些区域是否包含足够的神经表征来创建心理图像，或者是否需要与大脑中的其他区域（例如海马体（HC））相互作用，以从记忆中获取必要的信息。为了检验这一假设，我们使用了功能磁共振成像以及多体素模式分类和心理生理学相互作用分析。参与者在观看或想象熟悉环境的场景时被扫描。我们发现，在意象和感知过程中，熟悉地点的身份可以从海马旁位置区（PPA）、压后复合体/顶枕沟（RSC/POS）和 HC 的神经模式中解码出来，并且来自感知地点的特定信息在相同地点的心理意象过程中被重新实例化，反之亦然。此外，根据执行的任务，正确的 PPA 与正确的 HC 和 RSC/POS 显着交互。具体来说，PPA 和 HC 之间的功能耦合在心理意象过程中较高，而 PPA 和 RSC/POS 之间的功能耦合在感知过程中较高。我们的研究为理解大脑如何使用先前获得的知识来构建世界的心理表征做出了重要贡献。 (C) 2016 Elsevier Inc. 保留所有权利。
Visual mental imagery arises when perceptual information is accessed from memory, originating the experience of "seeing with the mind's eye". Different content-dependent brain areas in the human ventral visual stream are activated during visual mental imagery, similarly to what happens during visual perception. The neural patterns within these regions, but not in the early visual cortex, are similar during imagery and perception, suggesting that, in the absence of perceptual stimulation, content-dependent brain areas are able to re-instantiate specific neural patterns allowing for mental imagery. However, it remains unknown whether these areas contain adequate neural representations that create mental images or need to interact with other regions in the brain, such as the hippocampus (HC), to access the necessary information from memory. To test this hypothesis, we used functional magnetic resonance imaging and both multivoxel pattern classification and psychophysiological interaction analyses. Participants were scanned while viewing or imagining scenes of familiar environments. We found that the identity of familiar places can be decoded from the neural patterns in the parahippocampal place area (PPA), retrosplenial complex/parieto-occipital sulcus (RSC/POS) and HC, during both imagery and perception, and that item-specific information from perceived places was re-instantiated during mental imagery of the same places and vice versa. Furthermore, the right PPA significantly interacted with the right HC and RSC/POS according to the performed task. Specifically, the functional coupling between PPA and HC was higher during mental imagery, whereas the functional coupling between PPA and RSC/POS was higher during perception. Our investigation provides an important contribution to the understanding of how the brain uses previously acquired knowledge to build a mental representation of the world. (C) 2016 Elsevier Inc. All rights reserved.