Amyloid enhancing factor (AEF) in the aging mouse
Amyloid enhancing factor (AEF) in the aging mouse
复制标题
衰老小鼠中的淀粉样蛋白增强因子（AEF）
作者：
T. Yokota;T. Ishihara;H. Kawano;Mutsuo Takahashi;Yoshihiro Fujinaga;F. Uchino
在 52、28 和 9 周龄未治疗小鼠的脾匀浆中测试了淀粉样蛋白增强因子 (AEF) 活性。 52 周龄小鼠的脾匀浆上清液中存在强 AEF 活性。 28周龄小鼠的上清液中仅观察到微弱的活性，而9周龄小鼠的上清液中未观察到任何活性。对 52 周龄小鼠的粗制脾匀浆进行 Sephacryl S-300 凝胶过滤。 AEF活性存在于第一个凝胶过滤峰中。这些发现表明，老年小鼠脾脏中的 AEF 增加，并且 AEF 可能是一种高分子量物质。
Amyloid enhancing factor (AEF) activity was tested in spleen homogenates from 52, 28, and 9-week-old untreated mice. Strong AEF activity was present in the supernatant of spleen homogenate from the 52-week-old mice. Only weak activity was observed in the supernatant from the 28-week-old mice, and none was seen in that from the 9-week-old mice. Crude spleen homogenates from the 52-week-old mice were subjected to Sephacryl S-300 gel filtration. AEF activity existed in the first gel filtration peak. These findings suggest that AEF increases in the spleens of aged mice and that AEF may be a substance of high molecular weight.
淀粉样蛋白增强因子的进一步表征。
DOI：
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发表时间：
1982
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
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作者：
Axelrad,MA;Kisilevsky,R;Willmer,J;Chen,SJ;Skinner,M
通讯作者：
Skinner,M