Relationship between Changes in Crystalline Lens Shape and Axial Elongation in Young Children
Relationship between Changes in Crystalline Lens Shape and Axial Elongation in Young Children
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DOI：
10.1167/iovs.12-10105
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发表时间：
2013-01-01
影响因子：
4.4
通讯作者：
Oshika, Tetsuro
中科院分区：
文献类型：
--
作者：
Ishii, Kotaro;Yamanari, Masahiro;Oshika, Tetsuro
目的。评价幼儿生长过程中晶状体形状变化与轴向伸长的关系。25例接受头部磁共振成像（MRI）检查的患者（年龄1个月至6岁）被纳入分析。用自折射仪测量22例患者的屈光不正。从MR图像中获得晶状体尺寸和轴向长度（AL）。利用重建的MR图像测量了晶状体的曲率半径和非球面性。在MR图像的基础上，用椭圆傅里叶描述子（EFDs）数值表达晶状体形状和眼球形状。用efds主成分分析评价晶状体和眼球的轮廓。平均前后曲率半径分别为6.21 mm （3.89 ~ 7.26 mm）和-4.81 mm （-2.93 ~ -5.67 mm）。经对数分析，这些指标与年龄密切相关。晶状体的第一主成分（PC1）解释了晶状体形状总方差的89.15%，与年龄（Pearson’s r = 0.648, P < 0.001）和AL （r = 0.847, P < 0.001）也有显著相关。在以AL为因变量的多元线性回归分析中，只有晶状体的PC1与AL相关。轴向伸长率与晶状体的整个轮廓有关。这一结果表明，轴向伸长率与晶状体形状的变化是平行的。（Invest Ophthalmol Vis Sci. 2013;54:771-777） DOI: 10.1167/iovs.12-10105
PURPOSE. To evaluate the relationship between changes in crystalline lens shape and axial elongation during growth in young children.METHODS. Twenty-five patients (age: 1 month to 6 years) who underwent head magnetic resonance imaging (MRI) were included in the analysis. Refractive error was measured with an autorefractor in 22 patients. Crystalline lens dimensions and axial length (AL) were obtained from the MR images. The radius of curvature and asphericity of the crystalline lens were measured using reconstructed MR images. Crystalline lens shape and eyeball shape were numerically expressed by elliptic Fourier descriptors (EFDs) on the basis of MR images. The contours of the crystalline lens and eyeball were evaluated by principal component analysis of the EFDs.RESULTS. The average anterior and posterior radii of curvature were 6.21 mm (range across ages from 3.89-7.26 mm) and -4.81 mm (range across ages from -2.93 to -5.67 mm). These were closely correlated with age by logarithmic analysis. The first principal component (PC1) of the crystalline lens explained 89.15% of the total variance in lens shape, and it was also significantly correlated with age (Pearson's r = 0.648, P < 0.001) and AL (r = 0.847, P < 0.001). In the multiple linear regression analysis in which AL was a dependent variable, only the PC1 of the crystalline lens was associated with AL.CONCLUSIONS. Axial elongation is related to the entire contour of the crystalline lens. This result shows that axial elongation progresses in parallel to change in the crystalline lens shape. (Invest Ophthalmol Vis Sci. 2013;54:771-777) DOI: 10.1167/iovs.12-10105