Olfactory Wiring Logic in Amphibians Challenges the Basic Assumptions of the Unbranched Axon Concept
Olfactory Wiring Logic in Amphibians Challenges the Basic Assumptions of the Unbranched Axon Concept
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DOI：
10.1523/jneurosci.2755-13.2013
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发表时间：
2013-10-30
影响因子：
5.3
通讯作者：
Manzini, Ivan
中科院分区：
文献类型：
--
作者：
Hassenkloever, Thomas;Manzini, Ivan
嗅觉受体神经元将轴突延伸到嗅球中，在那里它们面临着整合到现有电路中的挑战。一致的观点是，在脊椎动物中，单个受体神经元将不分支的轴突投射到嗅球的一个特定肾小球中。我们在这里报告，惊人的不同，从一般假设的布线原则在脊椎动物嗅觉系统，非洲爪蟾的单受体神经元的轴突定期分叉，并项目到一个以上的肾小球。具体而言，神经支配的多个肾小球是本物种的所有个体发育阶段，从幼虫到postmetamorphic青蛙。此外，我们表明，这种意想不到的布线模式不仅限于未成熟的受体神经元的轴突，但它也是一个功能的成熟神经元的主要和辅助嗅觉系统。这种肾小球神经支配模式是迄今为止研究的脊椎动物中唯一的，代表了一种新的嗅觉布线策略。
Olfactory receptor neurons extend axons into the olfactory bulb, where they face the challenge to integrate into existing circuitry. The consensus view is that in vertebrates individual receptor neurons project unbranched axons into one specific glomerulus of the olfactory bulb. Wereport here that, strikingly different from the generally assumed wiring principle in vertebrate olfactory systems, axons of single receptor neurons of Xenopus laevis regularly bifurcate and project into more than one glomerulus. Specifically, the innervation of multiple glomeruli is present in all ontogenetic stages of this species, from the larva to the postmetamorphic frog. Also, we show that this unexpected wiring pattern is not restricted to axons of immature receptor neurons, but that it is also a feature of mature neurons of both the main and accessory olfactory system. This glomerular innervation pattern is unique among vertebrates investigated so far and represents a new olfactory wiring strategy.