COVID-19 and post-mortem microbiological studies
COVID-19 and post-mortem microbiological studies
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DOI：
10.1016/j.remle.2020.05.007
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发表时间：
2020-07-15
期刊：
影响因子：
--
通讯作者：
Alberola J
中科院分区：
文献类型：
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作者：
Fernández-Rodríguez A;Casas I;Culebras E;Morilla E;Cohen MC;Alberola J
我们回顾了 COVID-19 感染的微生物学方面，并提出了应在法医案件中进行的微生物学研究。我们描述了该病毒的分类学特征、其与冠状病毒科的关系及其遗传结构。我们简要介绍了 COVID-19 感染的临床和病理特征，以及可能与该病毒相关的合并感染。在实验室中，PCR 以及抗原和血清学研究是感染急性期的首选技术。最后，我们描述了与 COVID-19 大流行相关的死者微生物学研究的主要目标，以及在法医学背景下进行的主要尸检微生物学分析。微生物学分析的目的应是检测 SARS-CoV-2 和合并感染，这也可能导致死亡。
We review the microbiological aspects of COVID-19 infection and present the microbiological studies that should be performed in forensic cases. We describe the taxonomic characteristics of the virus, its relationship with the coronaviridae family and its genetic structure. We briefly present the clinical and pathological characteristics of COVID-19 infection, as well as the co-infections that could be associated with this virus. In the laboratory, PCR is a first-choice technique in the acute phase of the infection, together with antigen and serological studies. Finally, we describe the main objectives of microbiological studies in the deceased in relation to the COVID-19 pandemic, as well as the main post-mortem microbiological analysis to be carried out in the medico-legal context. The microbiological analysis should aim to detect both SARS-CoV-2 and coinfections, which may also contribute to the cause of death.