Comorbid somatic symptoms and functional status in patients with fibromyalgia and chronic fatigue syndrome: Sensory amplification as a common mechanism
Comorbid somatic symptoms and functional status in patients with fibromyalgia and chronic fatigue syndrome: Sensory amplification as a common mechanism
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DOI：
10.1176/appi.psy.49.3.235
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发表时间：
2008-05-01
期刊：
影响因子：
3.4
通讯作者：
Williams, David A.
中科院分区：
文献类型：
--
作者：
Geisser, Michael E.;Donnell, Cathy Strader;Williams, David A.
背景：躯体症状在纤维肌痛（FM）和慢性疲劳综合征（CFS）等疾病中很常见。目的：作者研究了一种潜在的共同病理机制：一种普遍的感知异常，对各种感觉刺激（包括疼痛）的反应性增强。方法：在38例FM和/或CFS患者中，建立了感觉灵敏度的复合指标，并与躯体症状、共病心理障碍和自我报告的身体功能指标进行了比较。结果如下：感觉放大通过疼痛强度间接影响身体功能，身体症状和疲劳也独立地影响身体功能。结论：感觉放大可能是这些疾病的潜在病理生理机制，相对独立于抑郁症和抑郁症状。
Background: Somatic symptoms are common in conditions such as fibromyalgia (FM) and chronic fatigue syndrome (CFS). Objective: Authors investigated a potential shared pathologic mechanism: a generalized perceptual abnormality where there is heightened responsiveness to varied sensory stimulation, including pain. Method: A composite measure of sensory sensitivity was created and compared with measures of somatic symptoms, comorbid psychological disturbances, and self-reported physical functioning in 38 patients with FM and/or CFS. Results: Sensory amplification influenced physical functioning indirectly through pain intensity, and physical symptoms and fatigue also independently contributed to physical functioning. Conclusion: Sensory amplification may be an underlying pathophysiologic mechanism in these disorders that is relatively independent of depression and depressive symptoms.