Overview of hepatitis C virus genome structure, polyprotein processing, and protein properties.
Overview of hepatitis C virus genome structure, polyprotein processing, and protein properties.
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DOI：
10.1007/978-3-642-59605-6_4
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发表时间：
2000
影响因子：
--
通讯作者：
K. Reed;C. Rice
中科院分区：
文献类型：
--
作者：
K. Reed;C. Rice
Hepatitis C was first recognized as a distinct form of liver disease in the mid-1970s with the advent of diagnostic tests for hepatitis A and B virus infection (ALTERet al. 1975; PRINCEet al. 1974). The etiologic agent of hepatitis C was proposed to be a small, enveloped virus based on demonstrations of its transmissibility to chimpanzees (ALTERet al. 1978; HOLLINGERet al. 1978; TABORet al. 1978), small size (< 80nm) (BRADLEYet al. 1985; HEet al. 1987), and sensitivity to chloroform (BRADLEYet al. 1983; FEINSTONEet al. 1983). The genome of hepatitis C virus (HCV) was first cloned in 1989 by screening a λgt11 cDNA expression library, derived from the plasma of a persistently infected chimpanzee, with hepatitis C patient serum (CHOOet al. 1989). Hybridization and nuclease digestion experiments indicated that the HCV genome consists of a single-stranded, positive-sense, RNA molecule (CHOOet al. 1989).
