Consumption of sweetened beverages and intakes of fructose and glucose predict type 2 diabetes occurrence
Consumption of sweetened beverages and intakes of fructose and glucose predict type 2 diabetes occurrence
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DOI：
10.1093/jn/137.6.1447
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发表时间：
2007-06-01
影响因子：
4.2
通讯作者：
Reunanen, Antti
中科院分区：
文献类型：
--
作者：
Montonen, Jukka;Jarvinen, Ritva;Reunanen, Antti
在1967年至1972年的基线时，在4，304名40-60岁的男性和女性中研究了不同糖摄入量在2型糖尿病发展中的作用。通过饮食史访谈收集食物消耗数据，包括前一年的习惯饮食。计算不同糖的摄入量并将其分为四分位数。在为期12年的随访中，从全国范围内的登记中确定了177例2型糖尿病病例。果糖和葡萄糖的联合摄入与2型糖尿病的风险相关，但未观察到蔗糖、乳糖或麦芽糖的摄入与2型糖尿病的风险相关。果糖和葡萄糖联合摄入的最高和最低四分位数之间的相对风险为1.87（95% [Cl] = 1.19，2.93; P= 0.003）。相应的相对危险度，对于甜浆果汁和软饮料，导致糖摄入的食物的极端四分位数分别为1.69（95% [Cl] = 1.17，2.43; P < 0.001）和1.67（95% [Cl] = 0.98，2.87; P = 0.01）。我们的研究结果支持这样的观点，即摄入更多的果糖和葡萄糖以及含糖饮料可能会增加2型糖尿病的风险。
The role of intakes of different sugars in the development of type 2 diabetes was studied in a cohort of 4,304 men and women aged 40-60 y and initially free of diabetes at baseline in 1967-1972. Food consumption data were collected using a dietary history interview covering the habitual diet during the previous year. The intakes of different sugars were calculated and divided in quartiles. During a 12-y follow-up, 177 incidents of type 2 diabetes cases were identified from a nationwide register. Combined intake of fructose and glucose was associated with the risk of type 2 diabetes but no significant association was observed for intakes of sucrose, lactose, or maltose. The relative risk between the highest and lowest quartiles of combined fructose and glucose intake was 1.87 (95% [Cl] = 1.19, 2.93; P= 0.003). The corresponding relative risks between the extreme quartiles of consumption of food items contributing to sugar intakes were 1.69 (95% [Cl] = 1.17, 2.43; P < 0.001) for sweetened berry juice and 1.67 (95% [Cl] = 0.98, 2.87; P = 0.01) for soft drinks. Our findings support the view that higher intake of fructose and glucose and sweetened beverages may increase type 2 diabetes risk.