Defective gap junctional intercellular communication in lung cancer: loss of an important mediator of tissue homeostasis and phenotypic regulation.
Defective gap junctional intercellular communication in lung cancer: loss of an important mediator of tissue homeostasis and phenotypic regulation.
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肺癌中间隙连接细胞间通讯缺陷：组织稳态和表型调节的重要介质的丧失。
DOI：
10.1080/019021401300053984
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发表时间：
2001
影响因子：
1.7
通讯作者：
Malkinson,AM
中科院分区：
文献类型：
--
作者：
Ruch,RJ;Porter,S;Koffler,LD;Dwyer-Nield,LD;Malkinson,AM
间隙连接为相邻细胞之间的分子和离子交换提供了直接途径，这一过程称为间隙连接细胞间通讯（GJIC）。该GJIC对于有丝分裂、分化和凋亡的稳态和调节是重要的。缝隙连接存在于肺气道和肺泡上皮细胞中，除了上述作用外，还可能协调纤毛跳动和表面活性物质分泌。GJIC在人和小鼠肺癌细胞中减少，因为差距连接蛋白，连接蛋白43（Cx43）的表达减少，以及介导Cx43功能的信号转导通路的缺陷。这种减少的GJIC在肺癌细胞的行为中是重要的，因为肺癌细胞中Cx43的强制表达抑制了它们的生长和致瘤性。在这份报告中，我们总结了我们的研究GJIC在肺肿瘤的作用。
Gap junctions provide direct pathways for the exchange of molecules and ions between neighboring cells, a process known as gap junctional intercellular communication (GJIC). This GJIC is important for homeostasis and regulation of mitosis, differentiation, and apoptosis. Gap junctions are present in lung airway and alveolar epithelial cells and, in addition to the above roles, might coordinate ciliary beating and surfactant secretion. GJIC is decreased in human and mouse lung carcinoma cells because of reduced expression of the gap junction protein, connexin43 (Cx43), and defects in signal transduction pathways that mediate Cx43 function. This reduced GJIC is important in the behavior of lung carcinoma cells because forced expression of Cx43 in lung carcinoma cells inhibits their growth and tumorigenicity. In this report, we summarize our studies on the role of GJIC in lung neoplasia.