Puberty is an important developmental period for the establishment of adipose tissue mass and metabolic homeostasis
Puberty is an important developmental period for the establishment of adipose tissue mass and metabolic homeostasis
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DOI：
10.1080/21623945.2017.1349042
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发表时间：
2017-01-01
期刊：
影响因子：
3.3
通讯作者：
Rodeheffer, Matthew S.
中科院分区：
文献类型：
--
作者：
Holtrup, Brandon;Church, Christopher D.;Rodeheffer, Matthew S.
在过去的20年里，儿童肥胖症的发病率急剧上升。最近儿童肥胖症的增加尤其令人担忧，因为与成年后肥胖的个体相比，儿童时期肥胖的成年人患上了II型糖尿病，这对目前的治疗形式来说是难以治愈的。虽然与儿童肥胖相关的糖尿病表型恶化的机制尚不清楚，但众所周知，儿童期是人类建立正常白色脂肪组织的重要时期。这种关联表明，在脂肪发育过程中暴露于致肥刺激可能对脂肪功能和代谢稳态产生有害影响。在这项研究中，我们确定了与青春期相关的发育期，出生后第18-34天，作为建立小鼠正常脂肪量的关键。仅在这段时间内将小鼠暴露于高脂肪饮食导致代谢功能障碍、瘦素表达增加以及在没有持续增加的脂肪量或体重的情况下成年期脂肪细胞大小增加。这些研究结果表明，在关键发育期暴露于致肥胖刺激物对脂肪组织功能具有长期影响，这可能导致与儿童肥胖相关的代谢功能障碍加剧。
Over the past 2 decades, the incidence of childhood obesity has risen dramatically. This recent rise in childhood obesity is particularly concerning as adults who were obese during childhood develop type II diabetes that is intractable to current forms of treatment compared with individuals who develop obesity in adulthood. While the mechanisms responsible for the exacerbated diabetic phenotype associated with childhood obesity is not clear, it is well known that childhood is an important time period for the establishment of normal white adipose tissue in humans. This association suggests that exposure to obesogenic stimuli during adipose development may have detrimental effects on adipose function and metabolic homeostasis. In this study, we identify the period of development associated with puberty, postnatal days 18-34, as critical for the establishment of normal adipose mass in mice. Exposure of mice to high fat diet only during this time period results in metabolic dysfunction, increased leptin expression, and increased adipocyte size in adulthood in the absence of sustained increased fat mass or body weight. These findings indicate that exposure to obesogenic stimuli during critical developmental periods have prolonged effects on adipose tissue function that may contribute to the exacerbated metabolic dysfunctions associated with childhood obesity.