Infection of human pegivirus 2 (HPgV-2) is associated with hepatitis C virus but not hepatitis B virus infection in people who inject drugs
Infection of human pegivirus 2 (HPgV-2) is associated with hepatitis C virus but not hepatitis B virus infection in people who inject drugs
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注射吸毒者中人类佩吉病毒 2 (HPgV-2) 的感染与丙型肝炎病毒相关，但与乙型肝炎病毒感染无关
DOI：
10.1099/jgv.0.001266
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发表时间：
2019
影响因子：
3.8
通讯作者：
Shixing Tang
中科院分区：
文献类型：
--
作者：
Jingwei Shui;Wenpei Liu;Yuanhao Liang;Jian Zhang;Zhengwei Wan;Haiying Wang;Xiaowang Qu;Shixing Tang
为探讨人类巨细胞病毒2型(HPgV-2)感染与丙型肝炎病毒(丙型肝炎病毒/乙肝病毒)混合感染的关系，对745例丙型肝炎病毒阳性而人类免疫缺陷病毒1型(HIV-1)阴性的注射吸毒者中国进行了研究。抗-HPgV2阳性率为4.43%(33/745)，其中6a型明显高于非6a型，分别为6.29%(18/286)和1.69%(4/236)(P=0.009)。6a型与非6a型HPgV-2RNA阳性率分别为2.45%(7/286)和2.54%(6/236)，差异无统计学意义(P=0.945)。单纯感染乙肝病毒并不增加感染HPgV-2的风险。与丙型肝炎病毒单独感染相比，合并感染HPgV-2的风险增加约3倍：以抗-HPgV-2阳性或HPgV-2病毒血症为标准，优势比(OR)=3.241.34~7.82P=0.014。HPgV-2感染不会增加肝脏特异性酶的水平。我们的研究提供了关于HPgV-2与丙型肝炎病毒基因型以及丙型肝炎病毒/乙肝病毒混合感染的新发现。
We evaluated the association between human pegivirus-2 (HPgV-2) infection and hepatitis C virus (HCV)/hepatitis B virus (HBV) co-infection in 745 plasma samples collected from HCV-positive but human immunodeficiency virus type one (HIV-1)-negative people who inject drugs in Hunan, China. The prevalence of anti-HPgV-2 was 4.43 % (33/745) and, within this, the HCV 6a genotype showed significantly higher prevalence as compared with the HCV non-6a genotypes, 6.29 % (18/286) vs. 1.69 % (4/236), respectively (P=0.009). HPgV-2 RNA was detected in 2.15 % (16/745), and was not significantly different between the HCV 6a and non-6a genotypes, 2.45 % (7/286) vs. 2.54 % (6/236), respectively (P =0.945). HBV single infection did not increase the risk of HPgV-2 infection. Compared with HCV single infection, HCV/HBV co-infection increased the risk of HPgV-2 infection by about three-fold: odds ratio (OR)=3.24 [95 % confidence interval (CI) 1.34-7.82, P=0.014] according to anti-HPgV-2 positivity or OR=3.51 (95 % CI 1.15-10.74, P=0.051) according to HPgV-2 viraemia. HPgV-2 infection did not increase the levels of liver-specific enzymes. Our study provides new findings regarding the association between HPgV-2 and HCV genotypes as well as HCV/HBV co-infection.