Novel Strategies to Combat CMV-Related Cardiovascular Disease.
Novel Strategies to Combat CMV-Related Cardiovascular Disease.
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DOI：
10.20411/pai.v5i1.382
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发表时间：
2020
影响因子：
--
通讯作者：
Freeman ML
中科院分区：
文献类型：
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作者：
Vasilieva E;Gianella S;Freeman ML
巨细胞病毒（CMV）是一种无处不在的人类病原体，从未从宿主中清除，长期以来被认为在免疫功能正常的成年人中相对无害，但在新生儿和免疫功能低下的个体（如器官移植接受者和艾滋病患者）中引起严重的并发症，包括失明、终末器官疾病和死亡。然而，即使在免疫系统完整的人群中，巨细胞病毒感染也与免疫和炎症通路的深度刺激有关。巨细胞病毒感染携带者发生心血管并发症的风险也较高。在这篇综述中，我们定义了CMV如何导致心血管疾病（CVD）的机制，描述了当前靶向CMV的方法，并讨论了这些策略如何减轻CMV感染患者的心血管并发症。此外，我们讨论了在接受抗逆转录病毒治疗的HIV感染者中CMV合并感染的特殊情况，并描述了这两种病毒感染如何相互作用以增强这一特别易感人群的CVD。
Cytomegalovirus (CMV), a ubiquitous human pathogen that is never cleared from the host, has long been thought to be relatively innocuous in immunocompetent adults, but causes severe complications including blindness, end-organ disease, and death in newborns and in immuno-compromised individuals, such as organ transplant recipients and those suffering from AIDS. Yet even in persons with intact immunity, CMV infection is associated with profound stimulation of immune and inflammatory pathways. Carriers of CMV infection also have an elevated risk of developing cardiovascular complications. In this review, we define the proposed mechanisms of how CMV contributes to cardiovascular disease (CVD), describe current approaches to target CMV, and discuss how these strategies may or may not alleviate cardiovascular complications in those with CMV infection. In addition, we discuss the special situation of CMV coinfection in people with HIV infection receiving antiretroviral therapy, and describe how these 2 viral infections may interact to potentiate CVD in this especially vulnerable population.