Comparison of the clinical characteristics and mortalities of severe COVID-19 patients between pre- and post-menopause women and age-matched men.
Comparison of the clinical characteristics and mortalities of severe COVID-19 patients between pre- and post-menopause women and age-matched men.
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DOI：
10.18632/aging.203532
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发表时间：
2021-09-22
期刊：
影响因子：
--
通讯作者：
Xia Z
中科院分区：
文献类型：
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作者：
Liu D;Ding HL;Chen Y;Chen DH;Yang C;Yang LM;Liu JA;Zhang L;Xia ZY;Zhang XH;Lei S;Xia Z
据报道，年轻女性COVID-19患者的死亡率低于年轻男性，但65岁以上的女性和男性COVID-19患者的死亡率没有显著差异，其潜在机制尚不清楚。我们回顾性分析了绝经前后重症COVID-19患者的临床特征和结局，并与年龄匹配的男性进行了比较。在纳入的459例患者中，141例年龄≤55岁，其中19例死亡（男性16例，女性3例，p<0.005）。而对于>55岁的患者（n=318），115例死亡（47例女性vs. 68例男性，p=0.149）。在≤55岁的患者中，男性的NLR、中位LDH、中位C反应蛋白和降钙素原水平显著高于女性，而中位淋巴细胞计数和LCR低于女性（均p<0.0001）。在55岁以上的患者中，这些生化参数在两种性别的绝大多数患者中远离相关正常/参考值，这与年轻组中观察到的情况相反。得出的结论是，患有严重疾病的绝经前但非绝经后COVID-19女性患者的死亡率低于年龄匹配的男性。我们的研究结果支持了雌激素在抗击COVID-19方面发挥有益作用的观点。
The mortality rate of young female COVID-19 patients is reported to be lower than that of young males but no significant difference in mortality was found between female and male COVID-19 patients aged over 65 years, and the underlying mechanism is unknown. We retrospectively analyzed clinical characteristics and outcomes of severely ill pre- and post-menopausal COVID-19 patients and compared with age-matched males. Of the 459 patients included, 141 aged ≤55, among whom 19 died (16 males vs. 3 females, p<0.005). While for patients >55 years (n=318), 115 died (47 females vs. 68 males, p=0.149). In patients ≤55 years old, the levels of NLR, median LDH, median c-reactive protein and procalcitonin were significantly higher while the median lymphocyte count and LCR were lower in male than in female (all p<0.0001). In patients over 55, these biochemical parameters were far away from related normal/reference values in the vast majority of these patients in both genders which were in contrast to that seen in the young group. It is concluded that the mortality of severely ill pre-menopausal but not post-menopausal COVID-19 female patients is lower than age-matched male. Our findings support the notion that estrogen plays a beneficial role in combating COVID-19.