STUbLs in chromatin and genome stability.
STUbLs in chromatin and genome stability.
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DOI：
10.1002/bip.22125
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发表时间：
2013-02
期刊：
影响因子：
2.9
通讯作者：
Pillus, Lorraine
中科院分区：
文献类型：
--
作者：
Garza, Renee;Pillus, Lorraine
染色质的结构和功能是基于核小体和染色质相关蛋白之间的动态相互作用。除了本期《生物聚合物》综述中考虑的其他翻译后修饰外，泛素和相扑蛋白在染色质功能中也发挥着重要作用。一种涉及两者的特殊形式的修饰，称为相扑靶向泛素连接，或STUbL[Perry，Tainer，and Boddy，Trends Biochem Sci，2008，33,201-208]，对核功能有重大影响，从基因调控到基因组稳定性。相扑和泛素在蛋白质修饰中的交叉点是最近一项全面综述的主题[Praefcke，Hofmann，and Dohman，Trends Biochem Sci，2012，37，23-31]。我们的目标是集中于具有STUbL活性的酶的特征，这些特征已经被研究得最好，特别是与它们在人类、苍蝇和酵母中的核功能有关的特征。由于后生动物中STUbL活性的丧失与疾病和发育有明显的关联，因此更多地了解它们的功能、调节和底物仍将是未来的重要目标。©2012 Wiley期刊，Inc.生物聚合物99：146-154,2013。
Chromatin structure and function is based on the dynamic interactions between nucleosomes and chromatin‐associated proteins. In addition to the other post‐translational modifications considered in this review issue of Biopolymers, ubiquitin and SUMO proteins also have prominent roles in chromatin function. A specialized form of modification that involves both, referred to as SUMO‐targeted ubiquitin ligation, or STUbL [Perry, Tainer, and Boddy, Trends Biochem Sci, 2008, 33, 201–208], has significant effects on nuclear functions, ranging from gene regulation to genomic stability. Intersections between SUMO and ubiquitin in protein modification have been the subject of a recent comprehensive review [Praefcke, Hofmann, and Dohmen, Trends Biochem Sci, 2012, 37, 23–31]. Our goal here is to focus on features of enzymes with STUbL activity that have been best studied, particularly in relation to their nuclear functions in humans, flies, and yeasts. Because there are clear associations of disease and development upon loss of STUbL activities in metazoans, learning more about their function, regulation, and substrates will remain an important goal for the future. © 2012 Wiley Periodicals, Inc. Biopolymers 99: 146–154, 2013.
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影响因子：
3.3
作者：
Geoffroy MC;Jaffray EG;Walker KJ;Hay RT
通讯作者：
Hay RT
影响因子：
4.6
作者：
Barry, Kevin C.;Abed, Mona;Parkhurst, Susan M.
通讯作者：
Parkhurst, Susan M.
影响因子：
4.5
作者：
Heideker J;Prudden J;Perry JJ;Tainer JA;Boddy MN
通讯作者：
Boddy MN
影响因子：
10.5
作者：
Galanty, Yaron;Belotserkovskaya, Rimma;Jackson, Stephen P.
通讯作者：
Jackson, Stephen P.
DOI：
10.1073/pnas.1200854109
发表时间：
2012-04-17
影响因子：
11.1
作者：
Geng, Fuqiang;Tansey, William P.
通讯作者：
Tansey, William P.