Heart-rate variability of carbon disulfide-poisoned subjects in Korea
Heart-rate variability of carbon disulfide-poisoned subjects in Korea
复制标题
DOI：
10.1007/s00420-002-0391-8
复制
发表时间：
2003-03-01
影响因子：
3
通讯作者：
Paek, D
中科院分区：
文献类型：
--
作者：
Jhun, HJ;Yim, SH;Paek, D
目的：韩国某粘胶人造丝厂发生二硫化碳（CS2）集体中毒事件。包括38人死亡在内，830名员工被诊断为CS2中毒。我们评估了CS2中毒受试者的心率变异性（HRV），以发现CS2是否可能影响HRV以及其毒性作用是否在暴露停止后持续存在。方法：病例组为71例CS2中毒的退休男工。对照组由127名相同年龄范围的公职人员组成，他们没有有机溶剂暴露史和心血管疾病史。通过体格检查和自填式问卷收集两组患者的个人年龄、身高、体重、吸烟、饮酒、定期运动、病史和职业史以及心电图记录等信息。分析两组的时间（最大、平均、最小RR间期）和频域测量值[低（LF）、高（HF）和总功率谱（TPS）]。结果如下：在单因素分析中，两组的时域测量值无显著差异，而病例组的频域测量值显著低于对照组（HF功率除外）。在多变量分析中，既往CS2中毒史与所有频域测量值呈负相关，并显著影响LF功率。结论：本研究表明，CS2可能会导致心率受损，其毒性作用持续暴露后停止。本研究结果表明，心率变异性测定可作为评价CS_2对在职和退休工人毒性作用的有效工具。
Objectives: Mass poisoning by carbon disulfide (CS2) occurred in a viscose-rayon factory in Korea. Including 38 who had died, 830 employees were diagnosed as CS2 poisoned. We evaluated the heart-rate variability (HRV) among CS2-poisoned subjects, to discover whether CS2 may affect HRV and whether its toxic effect persists after exposure has ceased. Methods: The case group comprised 71 retired male workers with CS2 poisoning. The control group comprised 127 public officials of the same age-range who had no history of organic-solvent exposure and cardiovascular diseases. Information on individual age, height, weight, cigarette smoking, alcohol drinking, regular exercise, medical and occupational history, and ECG recordings of the two groups were collected through medical examination and self-administered questionnaire. Time (maximum, average, minimum RR interval) and frequency domain measures [low (LF), high (HF), and total power spectrum (TPS)] of the two groups were analyzed. Results: In univariate analysis, time domain measures of the two groups did not differ significantly, while frequency domain measures in the case group was significantly lower than in the control group except for HF power. In multivariate analysis, previous history of CS2 poisoning was inversely related to all frequency domain measures and significantly affected LF power. Conclusions: This study suggests that CS2 may cause heart-rate impairment and its toxic effect persists after exposure has ceased. Based on this study, HRV measurement can be considered as a useful tool to assess toxic effects Of CS2 both in current and retired workers.