Evaluation of the clinical efficacy of a mouthwash and oral gel containing the antimicrobial proteins lactoperoxidase, lysozyme and lactoferrin in elderly patients with dry mouth--a pilot study.
Evaluation of the clinical efficacy of a mouthwash and oral gel containing the antimicrobial proteins lactoperoxidase, lysozyme and lactoferrin in elderly patients with dry mouth--a pilot study.
复制标题
评估含有抗菌蛋白乳过氧化物酶、溶菌酶和乳铁蛋白的漱口水和口腔凝胶对老年口干患者的临床疗效——一项试点研究。
作者：
J. Gil;Inmaculada Guardia;M. Gonzalez
目标
评价含有抗菌蛋白乳过氧化物酶、乳铁蛋白和溶菌酶的漱口水和口腔凝胶在老年口干患者样本中的临床疗效。
材料和方法
这项试点研究纳入了20名患有口干和日常生活活动有一定独立性的老年机构受试者。采用随机、双盲和交叉设计。研究变量包括主观口干感、通过视觉模拟量表（VAS）评估的不适严重程度、口腔健康影响概况（OHIP）、口干体征和症状的存在、唾液分泌量测定法和白色念珠菌培养。在两个研究阶段的每个阶段之前和之后记录所有变量。
结果
我们选择的20名受试者包括16名女性和4名男性，平均年龄为81.3岁。在分析第一和第二干预期之间的数据时，观察到OHIP值、口干的存在和吞咽液体的需要方面的改善。然而，治疗前后某些变量的改善并非在所有情况下都是积极的，有些受试者甚至在安慰剂治疗后有所改善。
结论
评价的漱口水和口腔凝胶改善了老年口干患者的一些主观和临床方面，尽管安慰剂效应不能完全排除。
OBJECTIVES
To evaluate the clinical efficacy of a mouthwash and oral gel containing the antimicrobial proteins lactoperoxidase, lactoferrin and lysozyme, in a sample of elderly individuals with dry mouth.
MATERIAL AND METHODS
Twenty elderly institutionalised subjects with dry mouth and with a certain degree of independence for daily life activities were included in this pilot study. A randomised, double blind and cross-over design was used. The study variables comprised subjective dry mouth sensation, the severity of discomfort assessed by means of a visual analogical scale (VAS), the Oral Health Impact Profile (OHIP), the presence of signs and symptoms of dry mouth, sialometry and Candida albicans culture. All the variables were recorded before and after each of the two periods of the study.
RESULTS
The 20 selected subjects we made up of 16 women and four men, with a mean age of 81.3 years. Improvement was observed on analysing the data between the first and second intervention period in terms of the OHIP values, the presence of dry mouth, and the need to drink fluids to swallow. However, the improvement in certain variables before and after treatment did not take a positive course in all cases, and some subjects even improved with placebo.
CONCLUSIONS
The evaluated mouthwash and oral gel improved some subjective and clinical aspects in elderly individuals with dry mouth, though a placebo effect cannot be entirely discarded.