Isomerization of Aziridines to Allyl Amines via Titanium and Chromium Cooperative Catalysis
Isomerization of Aziridines to Allyl Amines via Titanium and Chromium Cooperative Catalysis
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钛和铬协同催化氮丙啶异构化为烯丙胺
DOI：
10.1021/acs.joc.1c03054
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Norton, Jack R.
中科院分区：
文献类型：
--
作者：
Yao, Chengbo;Williams, Alana D.;Gu, Yiting;Norton, Jack R.
Ti/Cr协同催化剂在温和条件下将氮丙啶异构化为烯丙胺。该反应容许宽范围的具有各种氮取代基的氮杂环丙烷。钛催化剂在打开1，2-二取代氮杂环丙烷，以高度区域选择性的方式形成自由基中间体方面是最成功的。铬催化剂似乎从这些自由基中间体中提取了一个H·，然后将H·以H+和一个电子的形式返回到钛体系中，该反应与以前关于氮丙啶异构化为烯丙基胺的报道是互补的。
A Ti/Cr cooperative catalyst isomerizes aziridines to allyl amines under mild conditions. The reaction tolerates a broad range of aziridines with various nitrogen substituents. The titanium catalyst is most successful in opening 1,2-disubstituted aziridines, forming radical intermediates in a highly regioselective manner. The chromium catalyst appears to abstract an H•from these radical intermediates and then return the H•to the titanium system in the form of an H+and an electron. The reaction is complementary to previous reports on the isomerization of aziridines to allyl amines.