Oxidative stress, circulating antioxidants, and dietary preferences in songbirds
Oxidative stress, circulating antioxidants, and dietary preferences in songbirds
复制标题
DOI：
10.1016/j.cbpb.2012.12.005
复制
发表时间：
2013-03-01
影响因子：
2.2
通讯作者：
McWilliams, Scott R.
中科院分区：
文献类型：
--
作者：
Alan, Rebecca R.;McWilliams, Scott R.
氧化应激是新陈代谢不可避免的结果，在剧烈运动中会增加。这对于通过代谢脂肪来为长途飞行提供燃料的候鸟来说尤其成问题。鸟类可以通过增加内源性抗氧化剂（如尿酸）或食用膳食抗氧化剂（如生育酚）来减轻损害。在飞行过程中，鸟类可能会增加瘦肉组织的蛋白质催化剂，这可能会增加循环尿酸，许多鸟类在秋季迁徙期间也会消耗富含抗氧化剂的食果性饮食。我们评估了迁徙雀形目鸟类的三个相关假设：（1）蛋白质消耗与循环抗氧化剂呈正相关，（2）饮食氧化应激[即多不饱和脂肪酸（PUFA）]影响抗氧化能力和氧化损伤，（3）氧化应激影响饮食抗氧化剂偏好。白喉麻雀（Zonotrichia albicollis）消耗高蛋白饮食增加循环尿酸，然而，尿酸，抗氧化能力，氧化应激之间没有差异的鸟类消耗高PUFA与低PUFA饮食，尽管增加氧化损伤高PUFA鸟类。鸟类不喜欢富含抗氧化剂的饮食，即使在喂食高PUFA，低蛋白质。我们的结论是，白喉麻雀成功地减轻了与高PUFA饮食相关的氧化损伤，并建立了独立于尿酸，其他循环抗氧化剂和膳食抗氧化剂的内源性抗氧化反应。(c)2012 Elsevier Inc. All rights reserved.
Oxidative stress is an unavoidable consequence of metabolism and increases during intensive exercise. This is especially problematic for migratory birds that metabolize fat to fuel long-distance flight. Birds can mitigate damage by increasing endogenous antioxidants (e.g. uric acid) or by consuming dietary antioxidants (e.g. tocopherol). During flight, birds may increase protein catabolism of lean tissue which may increase circulating uric acid and many birds also consume an antioxidant-rich frugivorous diet during autumn migration. We evaluated three related hypotheses in a migratory passerine: (1) protein consumption is positively related to circulating antioxidants, (2) a dietary oxidative stressor [i.e. polyunsaturated fatty acid (PUFA)] influences antioxidant capacity and oxidative damage, and (3) oxidative stress influences dietary antioxidant preferences. White-throated Sparrows (Zonotrichia albicollis) consuming a high protein diet increased circulating uric acid; however, uric acid, antioxidant capacity, and oxidative stress did not differ between birds consuming a high PUFA versus a low PUFA diet, despite increased oxidative damage in high PUFA birds. Birds did not prefer antioxidant-rich diets even when fed high PUFA, low protein. We conclude that White-throated Sparrows successfully mitigated oxidative damage associated with a high PUFA diet and mounted an endogenous antioxidant response independent of uric acid, other circulating antioxidants, and dietary antioxidants. (c) 2012 Elsevier Inc. All rights reserved.