Neural magnetic field dependent fMRI toward direct functional connectivity measurements: A phantom study
Neural magnetic field dependent fMRI toward direct functional connectivity measurements: A phantom study
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DOI：
10.1038/s41598-020-62277-4
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发表时间：
2020-03-25
影响因子：
4.6
通讯作者：
Kobayashi, Tetsuo
中科院分区：
文献类型：
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作者：
Ito, Yosuke;Ueno, Masahito;Kobayashi, Tetsuo
最近，神经科学的主要问题一直是大脑功能连接的成像。然而，还没有一种可以直接测量功能连接的方法。在这里，我们展示了一种新的MRI序列，称为部分自旋锁序列，用于直接测量功能连接。本研究探讨了一个可能的测量相位差直接与功能连接。利用部分自旋锁成像，神经磁场可能会影响磁共振信号。使用仿真和幻影研究来模拟神经磁场，我们表明，磁共振信号的变化取决于外部施加的振荡磁场的相位与非右翻转角。这些结果表明，部分自旋锁序列是一个有前途的方式功能连接测量。
Recently, the main issue in neuroscience has been the imaging of the functional connectivity in the brain. No modality that can measure functional connectivity directly, however, has been developed yet. Here, we show the novel MRI sequence, called the partial spinlock sequence toward direct measurements of functional connectivity. This study investigates a probable measurement of phase differences directly associated with functional connectivity. By employing partial spinlock imaging, the neural magnetic field might influence the magnetic resonance signals. Using simulation and phantom studies to model the neural magnetic fields, we showed that magnetic resonance signals vary depending on the phase of an externally applied oscillating magnetic field with non-right flip angles. These results suggest that the partial spinlock sequence is a promising modality for functional connectivity measurements.