White Matter and Cognition in Adults Who Were Born Preterm
White Matter and Cognition in Adults Who Were Born Preterm
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DOI：
10.1371/journal.pone.0024525
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发表时间：
2011-10-12
期刊：
影响因子：
3.7
通讯作者：
Nosarti, Chiara
中科院分区：
文献类型：
--
作者：
Allin, Matthew P. G.;Kontis, Dimitris;Nosarti, Chiara
背景和目的：早产儿(胎龄33周前)是发育中脑白质损伤的危险因素，可能会影响以后的认知和行为。方法：应用弥散张量磁共振成像(DT-MRI)对80例早产儿和41例足月儿(平均年龄19.1岁，17-22岁，18.5岁，17-22岁)的脑白质微结构(分数各向异性；FA)进行了研究。VPT患者是1982-1984年出生队列的一部分，从出生起就进行了跟踪；足月患者是通过当地媒体广告招募的。结果：相对于术语组，VPT组有4个簇的FA减少，4个簇的FA增加，累及双侧大脑半球的多个联结区。在VPT组中，FA增加的簇与更严重的新生儿脑损伤相关。在VPT组中，FA降低的簇与出生体重降低和围产期缺氧有关，与成人认知能力下降有关。结论：VPT患者脑白质微结构的改变持续到成年，并与认知功能有关。
Background and Purpose: Individuals born very preterm (before 33 weeks of gestation, VPT) are at risk of damage to developing white matter, which may affect later cognition and behaviour.Methods: We used diffusion tensor MRI (DT-MRI) to assess white matter microstructure (fractional anisotropy; FA) in 80 VPT and 41 term-born individuals (mean age 19.1 years, range 17-22, and 18.5 years, range17-22 years, respectively). VPT individuals were part of a 1982-1984 birth cohort which had been followed up since birth; term individuals were recruited by local press advertisement. General intellectual function, executive function and memory were assessed.Results: The VPT group had reduced FA in four clusters, and increased FA in four clusters relative to the Term group, involving several association tracts of both hemispheres. Clusters of increased FA were associated with more severe neonatal brain injury in the VPT group. Clusters of reduced FA were associated with lower birth weight and perinatal hypoxia, and with reduced adult cognitive performance in the VPT group only.Conclusions: Alterations of white matter microstructure persist into adulthood in VPT individuals and are associated with cognitive function.