The association between late-life cognitive test scores and retrospective informant interview data
The association between late-life cognitive test scores and retrospective informant interview data
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晚年认知测试分数与回顾性知情人访谈数据之间的关联
DOI：
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发表时间：
2010
影响因子：
7
通讯作者：
C. Brayne
中科院分区：
文献类型：
--
作者：
R. Marioni;F. Matthews;C. Brayne
摘要背景：对老年人，特别是有功能障碍的老年人的认知评估，受到测量误差和测试痴呆症患者的伦理问题的阻碍。有关临终认知状态的有价值信息的潜在来源可以从那些非常了解被调查者的人那里获得--主要是亲戚或朋友。这项研究测试了生前的最后一次认知评估和回溯性的认知评估之间的关联。方法：分析来自医学研究委员会认知功能和老龄化研究的248名参与者的数据，他们的死亡年龄在71岁到102岁之间。采用简易精神状态检查量表(MMSE)在临死前0~8年评估晚年认知，并在死后0~7年采用回溯性告密者访谈(RINI)进行告密者测评。结果：零膨胀泊松回归显示MMSE得分和RINI得分之间有很强的相关性--那些在MMSE上得分29-30的人的RINI得分比那些得分<；18的人低4倍(p<；0.001)。MMSE到死亡之间的时间也是一个重要的预测因素，每增加一年，RINI评分就增加12.4%(p<；0.001)。死亡和RINI之间的时间只是一个重要的预测指标，当包括死亡后四年或更长时间采取的措施时。结论：回溯性访谈中的认知得分与晚年的MMSE得分密切相关。这表明，RINI可以被用来作为死亡前一段时间内认知能力的代理测量。
ABSTRACT Background: Cognitive assessment of older persons, particularly those with impairment, is hampered by measurement error and the ethical issues of testing people with dementia. A potential source of valuable information about end-of-life cognitive status can be gained from those who knew the respondent well – mostly relatives or friends. This study tested the association between last cognitive assessment before death and a retrospective informant assessment of cognition. Methods: Data were analyzed from 248 participants from the Medical Research Council Cognitive Function and Ageing Study who were aged 71 to 102 years at death. Late-life cognition was assessed 0 to 8 years before death using the Mini-mental State Examination (MMSE) and the informant measure was taken 0 to 7 years after death using a Retrospective Informant Interview (RInI). Results: Zero-inflated Poisson regression showed a strong association between MMSE scores and RInI scores – those scoring 29–30 on the MMSE had a RInI score four times lower than those who scored <18 (p < 0.001). The time between MMSE and death was also a significant predictor with each additional year increasing RInI scores by 12.4% (p < 0.001). The time between death and RInI was only a significant predictor when including measures that were taken four years or more after death. Conclusions: Cognitive scores from retrospective informant interviews are strongly associated with late-life MMSE scores taken close to death. This suggests that the RInI can be used as a proxy measure of cognition in the period leading up to death.