Volume of left amygdala subregion predicted temperamental trait of harm avoidance in female young subjects. A voxel-based morphometry study
Volume of left amygdala subregion predicted temperamental trait of harm avoidance in female young subjects. A voxel-based morphometry study
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DOI：
10.1016/j.brainres.2006.09.015
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发表时间：
2006-12-13
期刊：
影响因子：
2.9
通讯作者：
Sadato, Norihiro
中科院分区：
文献类型：
--
作者：
Iidaka, Tetsuya;Matsumoto, Atsushi;Sadato, Norihiro
本文采用标准问卷和高分辨率t1加权磁共振成像（MRI）对正常青年志愿者的气质倾向与大脑结构之间的关系进行了研究。56名受试者完成了日文版的气质与性格量表（TCI， 125项），并对大脑进行了核磁共振成像采集。利用统计参数映射和优化体素形态学（VBM）方法，从被试全脑图像中提取灰质（GM），并归一化为标准脑模板。以伤害避免（HA）分量表得分作为因变量，多元回归分析显示HA得分与左杏仁核部分体积呈正相关。兴趣区域分析显示，女性受试者的相关性显著，而男性受试者的相关性不显著。即使在考虑了年龄、抑郁评分和GM总量的影响后，相关性仍然显著。两性之间的差异相关性可能是由荷尔蒙状况的差异和妇女对社会心理压力的脆弱性引起的。此外，新颖性寻求（NS）得分与左额中回GM呈正相关。右尾状核尾部体积与奖励依赖（reward dependence， RD）得分呈正相关。在NS和RD评分方面，没有观察到显著的性别差异。这些结果表明，使用问卷测量的气质特征可能在人脑中具有形态学基础。(c) 2006 Elsevier B.V.版权所有
We investigated the relationship between temperamental predisposition and brain structure by using a standard questionnaire and high-resolution T1-weighted magnetic resonance image (MRI) in normal young volunteers. Fifty-six subjects completed the Japanese version of the Temperament and Character Inventory (TCI, 125 items) and underwent an MRI acquisition of the brain. The gray matter (GM) was extracted from the whole brain image of the subjects and normalized to the standard brain template using statistical parametric mapping and the optimized voxel-based morphometry (VBM) method. When the score on the harm avoidance (HA) subscale was used as a dependent variable, the multiple regression analysis revealed that the HA score positively correlated with the volume of the part of left amygdala. The region-of-interest analysis showed that the correlation was significant in the female subjects but not in the male subjects. The correlation was significant even after the effects of age, depression score, and total GM volume were taken into account. The differential correlation between the sexes may be caused by differences in hormonal condition and the vulnerability of women to socio-psychological stress. In addition, the novelty seeking (NS) score positively correlated with the GM of the left middle frontal gyrus. The volume of the tail of the right caudate nucleus positively correlated with the reward dependence (RD) score. With regard to the NS and RD scores, no significant sex difference was observed in the correlation. These results indicate that the temperamental traits measured using the questionnaire may have a morphological basis in the human brain. (c) 2006 Elsevier B.V. All rights reserved.